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Control of vascular permeability by polymorphonuclear leukocytes in inflammation

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Abstract

Polymorphonuclear leukocytes infiltrate tissues in response to an inflammatory stimulus to remove invading microorganisms and cell debris. We present evidence that these scavenging cells have another, more sophisticated role in that they are involved in the control of fluid efflux through the blood vessel wall which leads to tissue oedema.

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Authors and Affiliations

  1. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, London, WC2A 3PN, UK

    Caroline V. Wedmore & T. J. Williams

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  1. Caroline V. Wedmore
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  2. T. J. Williams
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Wedmore, C., Williams, T. Control of vascular permeability by polymorphonuclear leukocytes in inflammation. Nature 289, 646–650 (1981). https://doi.org/10.1038/289646a0

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  • DOI: https://doi.org/10.1038/289646a0

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