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The C1q receptor site on immunoglobulin G

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Abstract

We propose that, the binding site for the complement subcomponent C1q on immunoglobulin G involves the last two (C-terminal) β-strands of the Cγ2 domain. This region contains a large number of accessible and highly conserved charged residues and charge is postulated as an important component of the C1q–IgG interaction. The conclusions are reached on the basis of accessibility and sequence conservation analyses of Cγ2 amino acid residues, the use of specific inhibitors and chemical modification studies.

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Authors and Affiliations

  1. Department of Biochemistry and Laboratory of Molecular Biophysics, South Parks Road, Oxford, OX1 3QU, UK

    D. R. Burton, J. Boyd, A. D. Brampton, S. B. Easterbrook-Smith, E. J. Emanuel, J. Novotny, T. W. Rademacher, M. R. van Schravendijk, M. J. E. Sternberg & R. A. Dwek

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  1. D. R. Burton
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  2. J. Boyd
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  3. A. D. Brampton
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  4. S. B. Easterbrook-Smith
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  5. E. J. Emanuel
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  6. J. Novotny
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  7. T. W. Rademacher
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  8. M. R. van Schravendijk
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  9. M. J. E. Sternberg
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  10. R. A. Dwek
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Burton, D., Boyd, J., Brampton, A. et al. The C1q receptor site on immunoglobulin G. Nature 288, 338–344 (1980). https://doi.org/10.1038/288338a0

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  • DOI: https://doi.org/10.1038/288338a0

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