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H–2 restriction of contact inhibition of epithelial cells

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Abstract

Medawar has suggested1 that the major histocompatibility gene complex (MHC) might be involved in the contact inhibition of movement2 shown by fibroblasts and epithetia. Contact inhibition of movement3 is that reaction of cells which stops the movement of one cell over another and thus leads to monolayering and other features of morphology typical of cells in culture and in vivo4. By confronting epithelial outgrowths we have compared contact inhibition between syngeneic cells with that between allogeneic cells. Contact inhibition was more marked between allogeneic combinations than syngeneic combinations, when the genetic mismatch lay in certain parts of the MHC complex.

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Authors and Affiliations

  1. Department of Cell Biology, University of Glasgow, Glasgow, UK

    A. S. G. Curtis & Paul Rooney

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  1. A. S. G. Curtis
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  2. Paul Rooney
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Curtis, A., Rooney, P. H–2 restriction of contact inhibition of epithelial cells. Nature 281, 222–223 (1979). https://doi.org/10.1038/281222a0

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  • DOI: https://doi.org/10.1038/281222a0

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