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T antigen is bound to a host protein in SY40-transformed cells

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Abstract

THE early region of the small DNA tumour virus, simian virus 40 (SV40), is known to code for at least two polypeptides, the t and T antigens (‘small t’ and ‘large T’). Both these polypeptides are expressed in cells transformed by the virus1–4, and the T antigen has been shown to be essential for both the initiation and maintenance of the transformed state5–9. We therefore need to know how this T protein interacts with components of the host cell in order to understand the mechanism of SV40-induced transformation. We report here that the T antigen in a line of SV40-transformed mouse cells forms an oligomeric complex with a specific cell coded protein.

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Author notes

  1. D. P. LANE

    Present address: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

Authors and Affiliations

  1. Department of Zoology, Imperial College, London, SW7, UK

    D. P. LANE

  2. Department of Molecular Virology, Imperial Cancer Research Fund, London, WC2, UK

    L. V. CRAWFORD

Authors
  1. D. P. LANE
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  2. L. V. CRAWFORD
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LANE, D., CRAWFORD, L. T antigen is bound to a host protein in SY40-transformed cells. Nature 278, 261–263 (1979). https://doi.org/10.1038/278261a0

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  • DOI: https://doi.org/10.1038/278261a0

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