Skip to main content
SpringerLink
Log in

Fibronectin binds to Staphylococcus aureus

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

MANY important activities have been ascribed to fibronectin, which is found in soluble form in many biological fluids and in insoluble form on the surface of fibroblasts1–3. Fibronectin mediates the attachment of fibroblasts and hepatocytes to culture dishes4–6 and, when solubilised from the fibroblast surface, it binds to the surface of cultured transformed fibroblasts, restoring their morphology to normal7,8. I now report that the affinity of fibronectin to cell surfaces extends to the prokaryotic cell Staphylococcus aureus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hynes, R. O. Biochim. biophys. Acta 458, 73 (1976).

    CAS  PubMed  Google Scholar 

  2. Vaheri, A., Ruoslahti, E. & Mosher, D. (eds), Fibroblast Surface Protein (Ann. N. Y. Acad. Sci. 1978).

  3. Morrison, P. R., Edsall, J. T. & Miller, S. G. J. Am. chem. Soc. 70, 3103 (1948).

    Article  CAS  PubMed  Google Scholar 

  4. Klebe, R. J. Nature 250, 248 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Pearlstein, E. Nature 262, 497 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Höök, M., Rurin, K., Oldberg, Å., Öbrink, B. & Vaheri, A. Biochem. biophys. Res. Commun. 79, 726 (1977).

    Article  PubMed  Google Scholar 

  7. Yamada, K. M., Yamada, S. S. & Pastan, I. Proc. natn. Acad. Sci. U.S.A. 73, 1217 (1976).

    Article  ADS  CAS  Google Scholar 

  8. Ali, I. U., Mautner, V., Lanza, R. & Hynes, R., Cell 11, 115 (1977).

    Article  CAS  PubMed  Google Scholar 

  9. Ruoslahti, E., Vuento, M. & Engvall, E. Biochim. biophys. Acta 534, 210 (1978).

    Article  CAS  PubMed  Google Scholar 

  10. Grinnell, F. Expl Cell Res. 102, 51 (1976).

    Article  CAS  Google Scholar 

  11. Engvall, E. & Ruoslahti, E. Int. J. Cancer 20, 1 (1977).

    Article  CAS  PubMed  Google Scholar 

  12. Laemmli, U. K. Nature 227, 680 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunology, City of Hope National Medical Center, Duarte, California, 91010

    PENTTI KUUSELA

Authors
  1. PENTTI KUUSELA
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

KUUSELA, P. Fibronectin binds to Staphylococcus aureus. Nature 276, 718–720 (1978). https://doi.org/10.1038/276718a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/276718a0

  • Springer Nature Limited

This article is cited by

Search

Navigation