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A two-step fibrinogen–fibrin transition in blood coagulation

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Abstract

The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation sites.

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Authors and Affiliations

  1. Department of Blood Coagulation Research, Karolinska Institutet, Stockholm, Sweden

    Birger Blombäck, Birgit Hessel, Desmond Hogg & Lisbeth Therkildsen

  2. New York Blood Center, New York, New York

    Birger Blombäck, Birgit Hessel, Desmond Hogg & Lisbeth Therkildsen

Authors
  1. Birger Blombäck
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  2. Birgit Hessel
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  3. Desmond Hogg
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  4. Lisbeth Therkildsen
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Blombäck, B., Hessel, B., Hogg, D. et al. A two-step fibrinogen–fibrin transition in blood coagulation. Nature 275, 501–505 (1978). https://doi.org/10.1038/275501a0

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