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Cytochalasin D induces the capping of both leukaemia viral proteins and actin in infected cells

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Abstract

IT has been reported that cytochalasin B (CB) inhibits a cell-cycle-dependent step of Kirsten murine sarcoma–leukaemia virus maturation1. As CB inhibits hexose transport and acts on contractile elements2, the inhibition of virus maturation could be due to a hexose deficiency, the disruption of microfilaments, or some combination of the two effects. Because cytochalasin D (CD) seems to have only one effect, the disruption of microfilaments3–6, we used it here to study the role of microfilament organisation in the production of Moloney murine leukaemia virus (MLV). We report that actin and MLV structural proteins co-migrate in infected cells after CD treatment.

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Authors and Affiliations

  1. Department of Biochemistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1

    G. Y. MOUSA & J. R. TREVITHICK

  2. Cancer Research Laboratory, University of Western Ontario, London, Ontario, Canada, N6A 5B7

    J. BECHBERGER & D. G. BLAIR

Authors
  1. G. Y. MOUSA
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  2. J. R. TREVITHICK
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  3. J. BECHBERGER
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  4. D. G. BLAIR
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MOUSA, G., TREVITHICK, J., BECHBERGER, J. et al. Cytochalasin D induces the capping of both leukaemia viral proteins and actin in infected cells. Nature 274, 808–809 (1978). https://doi.org/10.1038/274808a0

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