Abstract
The ability of vitamin A and its analogues (retinoids) to prevent chemically-induced tumours has been studied in various experimental systems1. We have investigated here the possibility that retinoids might also inhibit radiation-induced oncogenic transformation using a cell line of C3H mouse embryo fibroblasts grown in culture. We report a marked reduction in the transformation frequency by using one such compound, Ro-11-1430, the synthesis and structure of which has been described by Bollag2.
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HARISIADIS, L., MILLER, R., HALL, E. et al. A vitamin A analogue inhibits radiation-induced oncogenic transformation. Nature 274, 486–487 (1978). https://doi.org/10.1038/274486a0
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DOI: https://doi.org/10.1038/274486a0
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