Abstract
THERE are two major types of genetic control of antibody responses. One is linked to immunoglobulin (Ig) allotype, and the relevant genes are Ig heavy-chain variable-region genes, which control receptor structures on B cells1. The other major region controlling immune responses lies in the major histo-compatibility complex (MHC), a genetic region discovered due to its predominant influence on graft reactions, but also containing immune response (Ir) genes2. The mode of action of the MHC-linked Ir genes is not known. Many hypotheses have been proposed both for their cellular site of action, that is, on T cells, B cells or macrophages, and for their mechanism of action2–4. Recently, we discussed the possibility that as macrophages are required for T and B lymphocyte activities, the available data were compatible with Ir genes expressed at the macrophage–lymphocyte interactions, with either T cells or B cells5. Results implying the involvement of macrophage Ir genes in the macrophage–T lymphocyte interaction have been reported in several species and systems, and include antigen induced proliferation in guinea pigs and mice6,7, and delayedtype hypersensitivity responses8. We report here the first evidence for macrophage Ir genes at the macrophage–B cell interaction.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Immun. Rev., Vol. 34 (ed. Moller, G.) (Munskguard, Copenhagen, 1976).
Benacerraf, B. & McDevitt, H. O. Science 175, 273–275 (1972).
Munro, A. J. & Taussig, M. J. Nature 256, 103–106 (1975).
Kapp, J., Pierce, C. W. & Benacerraf, B. J. exp. Med. 140, 172–184 (1974).
Feldmann, M. Nature 267, 107 (1977).
Shevach, E. & Rosenthal, A. S. J. exp. Med. 138, 1213–1229 (1973).
Schwartz, R. H., Yono, A. & Paul, W. E. in Ir Genes and Io Antigens (ed. McDevitt, H. O.) 297 (Academic, New York, 1978).
Miller, J. F. A. P., Vadas, M., Whitelaw, A., Gamble, J. & Bernard, C. J. exp. Med. 145, 1623–1628 (1977).
Howie, S. & Feldmann, M. Eur J. Immun. 7, 417–421 (1977).
Feldmann, M. J. exp. Med. 136, 737–760 (1972).
Erb, P. & Feldmann, M. Nature 254, 352–354 (1975).
Kapp, J., Pierce, C. W. & Benacerraf, B. J. exp. Med. 138, 1121–1132 (1973).
Dutton, R. W., McCarthy, M., Mishell, R. I. & Roudt, D. J. Cell. Immun. 1, 196–202 (1970).
Yono, A., Schwartz, R. M. & Paul, W. E. Eur. J. Immun. (in the press).
Feldmann, M. & Nossal, G. J. V. Transplantation 13, 3–34 (1972).
Rosenthal, A. S., Barcinski, M. & Blake, J. T. Nature 267, 156–158 (1977).
Thomas, D., Yamashita, U. & Shevach, E. M. J. Immun. 119, 223–226 (1977).
Schwartz, R. H. & Paul, W. E. J. exp. Med. 143, 529 (1976).
Erb, P., Meier, B., Kraus, D., Von Boehmer, H. & Feldmann, M. Eur. J. Immun. (in the press).
Erb, P. & Feldmann, M. J. exp. Med. 142, 460–472 (1975).
Kantor, F. & Feldmann, M. Clin. exp. Immun. (submitted).
Sprent, J., Schwartz, R. H., Yono, A. & Paul, W. E. in Ir Genes and Io Antigens (ed. McDevitt, H. O.) 341 (Academic, New York, 1978).
Howie, S., Feldmann, M., Mozes, E. & Maurer, P. H. Immunology 32, 297–299 (1977).
Taussig, M. J. Nature 248, 234–235 (1974).
Feldmann, M., Greaves, M. F., Parker, D. C. & Rittenberg, M. B. Eur. J. Immun. 4, 591–597 (1974).
Parish, C. R., Kirov, S. M., Bowern, N. & Blanden, R. V. Eur. J. Immun. 4, 808 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HOWIE, S., FELDMANN, M. Immune response (Ir) genes expressed at macrophage–B lymphocyte interactions. Nature 273, 664–666 (1978). https://doi.org/10.1038/273664a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/273664a0
- Springer Nature Limited
This article is cited by
-
Helper and suppressor T cell factors
Springer Seminars in Immunopathology (1980)