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Suppressor T cells in experimental autoimmune haemolytic anaemia

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Abstract

IMMUNISATION of mice with cross-reacting rat erythrocytes results in the development of autoimmune haemolytic anaemia, as indicated by haematological studies and erythrocyte autoantibodies1,2. However, the disease is self-limiting in normal mouse strains, and we present here evidence for the activity of a suppressor T cell which specifically controls the autoantibody component of the response, while leaving the heteroantibody component unaffected.

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Authors and Affiliations

  1. Department of Immunology, Middlesex Hospital Medical School, London, UK

    A. COOKE, P. R. HUTCHINGS & J. H. L. PLAYFAIR

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  1. A. COOKE
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  2. P. R. HUTCHINGS
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  3. J. H. L. PLAYFAIR
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COOKE, A., HUTCHINGS, P. & PLAYFAIR, J. Suppressor T cells in experimental autoimmune haemolytic anaemia. Nature 273, 154–155 (1978). https://doi.org/10.1038/273154a0

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  • DOI: https://doi.org/10.1038/273154a0

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