Abstract
THE disadvantages encountered with radioisotopes, such as high costs, health hazards, limited variety of useable isotopes, short shelf-life of the labelled antigens and difficulties of introducing the radioactive isotope on to the antigen molecule, have stimulated the search for non-isotopic methods in immunological work1. We report here on the feasibility of a novel non-isotopic system for immunochemical studies and its possible use in immunoassays. The basic concept of the new system is the use of metal atoms in the form of their organometallic or co-ordination complexes as labelling agents for haptens or macromolecular antigens.
Similar content being viewed by others
References
Landon, J., Crookall, J. & McGregor, A. in Steroid Immunoassay (eds Cameron, E. H. D., Hillier, S. G. & Griffith, K.) 183–188 (Alpha Omega, Cardiff, 1975).
Leute, R. K., Ullman, E. F., Goldstein, A. & Herzenberg, L. A. Nature new Biol. 236, 93–95 (1972).
Cais, M., Dani, S., Josephy, Y., Modiano, A., Gershon, H. & Mechoulam, R. FEBS Lett. 55, 257–260 (1975).
Cuatrecasas, F. & Anfinsen, C. B. Meth. Enzym. 22, 345–378 (1971).
Price, W. J. Analytical Atomic Absorption Spectrometry (Heyden, London, New York and Rheine, 1974).
Methods of Hormone Radioimmunoassay (eds Jaffe, B. M. & Behrman, H. R.) 473–476 (Academic, New York and London, 1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CAIS, M., DANI, S., EDEN, Y. et al. Metalloimmunoassay. Nature 270, 534–535 (1977). https://doi.org/10.1038/270534a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/270534a0
- Springer Nature Limited
This article is cited by
-
Ag nanoparticles outperform Au nanoparticles for the use as label in electrochemical point-of-care sensors
Analytical and Bioanalytical Chemistry (2022)
-
Sol particle immunoassays using colloidal gold and neutron activation
Journal of Radioanalytical and Nuclear Chemistry Articles (1993)