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Actin and tubulin co-cap with surface immunoglobulins in mouse B lymphocytes

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Abstract

CYTOSKELETAL control of cell surface receptor movements1 has been suggested by several authors2,3 and is compatible with the fluid mosaic model of cell membranes4. Evidence for this hypothesis comes mostly from experiments using drugs which alter the activity of cytoskeletal components3,5,6. We report here co-capping of actin and tubulin with immunoglobulins (Ig) in B lymphocytes from mouse spleen. These findings provide structural evidence for cytoskeletal control of receptors.

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Authors and Affiliations

  1. Department of Pathology, University of Geneva, 40 Boulevard de la Cluse, 1211 Geneva 4, Switzerland

    GIULIO GABBIANI, CHRISTINE CHAPONNIER, ALBERT ZUMBE & PIERRE VASSALLI

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  1. GIULIO GABBIANI
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  2. CHRISTINE CHAPONNIER
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  3. ALBERT ZUMBE
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  4. PIERRE VASSALLI
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GABBIANI, G., CHAPONNIER, C., ZUMBE, A. et al. Actin and tubulin co-cap with surface immunoglobulins in mouse B lymphocytes. Nature 269, 697–698 (1977). https://doi.org/10.1038/269697a0

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  • DOI: https://doi.org/10.1038/269697a0

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