Abstract
THERE is almost no information on the mutagenic effectiveness of the various ionising radiations for man and only limited information about radiations other than X or γ rays for experimental mammals. We have measured inactivation and mutation induction in cultured mammalian cells exposed to various radiations covering a range of linear energy transfer (LET; ref. 1). We show for two cell types that the maximum mutagenic effectiveness of these radiations, relative to X or γ rays, is about twice that for inactivation. Preliminary experiments suggest that specific chromosome aberrations may be associated with mutations induced by radiations of high LET.
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Cox, R., THACKER, J., GOODHEAD, D. et al. Mutation and inactivation of mammalian cells by various ionising radiations. Nature 267, 425–427 (1977). https://doi.org/10.1038/267425a0
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DOI: https://doi.org/10.1038/267425a0
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