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Prostaglandin E2-9-ketoreductase as a mediator of salt intake-related prostaglandin-renin interaction

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Abstract

PREVIOUS studies have revealed a close relationship between the prostaglandin (PG) and the renin–angiotensin systems in the kidney1–4 and we assume that both systems are intimately involved in the regulation of salt and volume homeostasis and of blood pressure. Changes in NaCl and water balance were found to be important determinants of the activity and function of the renin–angiotensin system5 and it has been suggested that PG synthesis is also modified by these variables2,6,7. One factor influencing the pathway and, thus, the consequences of altered PG formation is the enzyme PGE2-9-ketoreductase, which catalyses the interconversion of the antagonistically acting PGE2 and PGF2α (ref. 8). First direct evidence is presented here that PGE2-9-ketoreductase activity is under the control of NaCl ingestion. We suggest that this enzyme is an important mediator of salt intake-related prostaglandin–renin interaction.

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References

  1. Larsson, C., Weber, P. & Änggård, E. Eur. J. Pharmac. 28, 391–394 (1974).

    Article  CAS  Google Scholar 

  2. Weber, P. C., Holzgreve, H., Stephan, R. & Herbst, R. Eur. J. Pharmac. 34, 299–304 (1975).

    Article  CAS  Google Scholar 

  3. Änggård, E., Larsson, C. & Weber, P. C. in Advances in Proslaglandin and Thromboxane Research 2 (eds. Samuelsson, B. & Paoletti, R.) 587–594 (Raven, New York, 1976).

    Google Scholar 

  4. Bolger, P. M., Eisner, G. M., Ramwell, P. W. & Slotkoff, L. M. Nature 259, 244–245 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Gross, F. in Kidney Hormones (ed. Fischer, J. W.) 102–116 (Academic, New York, 1971).

    Google Scholar 

  6. McGiff, J. C., Itskovitz, H. D., Terragno, A. & Wong, P. Y.-K. Fedn Proc. 35, 175–180 (1976).

    CAS  Google Scholar 

  7. Tobian, L., O'Donnell, M. & Smith, D. Circulat. Res. 35, suppl. I, 83–86 (1974).

    Google Scholar 

  8. Leslie, C. A. & Levine, L. Biochem. biophys. Res. Commun. 52, 717–724 (1973).

    Article  CAS  PubMed  Google Scholar 

  9. Stone, K. J. & Hart, M. Prostaglandins 10, 273–288 (1975).

    Article  CAS  PubMed  Google Scholar 

  10. Katzen, D. R., Pong, S.-S. & Levine, L. Res. Com. Chem. Path. Pharmac. 12, 781–787 (1975).

    CAS  Google Scholar 

  11. Frölich, J. C. et al. J. clin. Invest. 55, 763–770 (1975).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Gill, J. R. et al. Am. J. Med. 61, 43–51 (1976).

    Article  PubMed  Google Scholar 

  13. Weber, P. C. et al. Circulat. Res. 39, 868–874 (1976).

    Article  CAS  Google Scholar 

  14. Dew, M. E. & Michelakis, A. M. Pharmacologist 16, 198A (1974).

    Google Scholar 

  15. Weber, P. C., Scherer, B. & Larsson, C. Eur. J. Pharmac. (in press).

  16. Stitzer, S. O. & Martinez-Maldonado, M. Am. J. Physiol. 230, 1550–1554 (1976).

    Article  CAS  PubMed  Google Scholar 

  17. Orloff, J., Handler, J. S. & Bergström, S. Nature 205, 397–398 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Lipson, L. C. & Sharp, G. W. G. Am. J. Physiol. 220, 1046–1052 (1971).

    Article  CAS  PubMed  Google Scholar 

  19. Gimbrone, M. A., Jr, & Alexander, R. W. Science 189, 219–220 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Wong, P. Y.-K., Terragno, A. N., Terragno, A. & McGiff, J. C. Physiologist 18, 455A (1975).

    Google Scholar 

  21. Swales, J. D., Tange, J. D. & Thurston, H. Circulat. Res. 37, 96–100 (1975).

    Article  CAS  PubMed  Google Scholar 

  22. Guyton, A. C., Coleman, T. G. & Granger, H. J. in A. Rev. Physiol. 34, 13–46 (1972).

    Article  CAS  Google Scholar 

  23. Weber, P. C., Held, E., Uhlich, E. & Eigler, J. O. C., Kidney Int. 7, 331–341 (1975).

    Article  CAS  PubMed  Google Scholar 

  24. Weeks, J. R., Schulz, J. R. & Brown, W. E. J. appl. Physiol. 25, 783–785 (1968).

    Article  CAS  PubMed  Google Scholar 

  25. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. biol. Chem. 193, 265–275 (1951).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, University Hospital, Ziemssenstrasse 1, 8000, Munich, 2, West Germany

    PETER C. WEBER, CARIN LARSSON & BURKHARD SCHERER

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  1. PETER C. WEBER
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  2. CARIN LARSSON
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WEBER, P., LARSSON, C. & SCHERER, B. Prostaglandin E2-9-ketoreductase as a mediator of salt intake-related prostaglandin-renin interaction. Nature 266, 65–66 (1977). https://doi.org/10.1038/266065a0

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