Abstract
Normal cells in culture have membrane receptors for epidermal growth factor (EGF); EGF stimulates cells to divide by binding to these receptors. Cells transformed by murine and feline sarcoma viruses rapidly lose the ability to bind EGF, whereas cells transformed by the DNA tumour viruses, polyoma and SV40, or infected with non-transforming RNA tumour viruses have normal levels of functional EGF receptors. The results suggest that a produce of the sarcoma virus genome specifically changes cell EGF receptors; the sarcoma gene product may, then, be functionally related to EGF.
Similar content being viewed by others
References
Gross, L., in Oncogenic Viruses, second ed. (Pergamon Press, Oxford, 1970).
Tooze, J., in The Molecular Biology of Tumour Viruses (Cold Spring Harbor Press, New York, 1973).
Wyke, J. A., Bell, J. G., and Beamand, J. A., Cold Spring Harb. Symp. quant. Biol., 39, 897–905 (1974).
Huebner, R., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 64, 1087–1094 (1969).
Todaro, G. J., and Huebner, R. J., Proc. natn. Acad. Sci. U.S.A., 69, 1009–1015 (1972).
Scolnick, E. M., Maryak, J. M., and Parks, W. P., J. Virol., 14, 1435–1444 (1974).
Lai, M. M.-C., Duesberg, P. H., Horst, J., and Vogt, P. K., Proc. natn. Acad. Sci. U.S.A., 70, 2266–2271 (1973).
Stehelin, D., Guntaka, R. V., Varmus, H. E., and Bishop, J. M., J. molec. Biol., 101, 349–365 (1976).
Stehelin, D., Varmus, H. E., Bishop, J. M., and Vogt, P. K., Nature, 260, 170–173 (1976).
Scolnick, E. M., Goldberg, R. J., and Williams, D., J. Virol., 18, 559–566 (1976).
Frankel, A. E., and Fischinger, P. J., J. Virol. (in the press).
Cohen, S., Carpenter, G., and Lembach, K. J., Adv. Metab. Disord., 8, 265–284 (1975).
Cohen, S., J. biol. Chem., 237, 1555–1562 (1962).
Cohen, S., and Taylor, J. M., in Recent Progress in Hormone Research (edit. by Creep, R. O.), 30, 533–550 (Academic, New York, 1974).
Cohen, S., and Savage, C. R., Jr, in Recent Progress in Hormone Research (edit. by Greep, R. O.), 30, 551–574 (Academic, New York, 1974).
Turkington, R. W., Expl Cell Res., 57, 69–85 (1969).
Armelin, H. A., Proc. natn. Acad. Sci. U.S.A., 70, 2702–2706 (1973).
Rose, S. P., Pruss, R. M., and Herschman, H. R., J. cell. Physiol., 86, 593–598 (1975).
Hollenberg, M. D., and Cuatrecasas, P., Proc. natn. Acad. Sci. U.S.A., 70, 2964–2968 (1973).
Westermark, B., Biochem. biophys. Res. Commun., 69, 304–310 (1976).
Cohen, S., and Carpenter, G., Proc. natn. Acad. Sci. U.S.A., 72, 1317–1321 (1975).
Gregory, H., Nature, 257, 325–327 (1975).
Roth, J., Metabolism, 22, 1059–1073 (1973).
Carpenter, G., Lembach, K. J., Morrison, M. M., and Cohen, S., J. biol. Chem., 250 4297–4304 (1975).
Hollenberg, M. D., and Cuatrecasas, P., J. biol. Chem., 250, 3845–3853 (1975).
Todaro, G. J., and Green, H., J. Cell Biol., 17, 299–313 (1963).
Aaronson, S. A., and Todaro, G. J., Science, 162, 1024–1026 (1968).
Jainchill, J. L., Aaronson, S. A., and Todaro, G. J., J. Virol., 4, 549–553 (1969).
Moloney, J. B., Symp. Zool. Soc. Lond., 17, 251–258 (1966).
Kirsten, W. H., and Mayer, L. A., J. natn. Cancer Inst., 39, 311–335 (1967).
Todaro, G. J., Green, H., and Goldberg, B. D., Proc. natn. Acad. Sci. U.S.A., 51, 66–73 (1964).
Todaro, G. J., Habel, K., and Green, H., Virology, 27, 179–185 (1965).
Benjamin, T. L., J. molec. Biol., 16, 359–373 (1966).
Duc-Nguyen, H., Rosenblum, E. N., and Zeigel, R. F., J. Bact., 92, 1133–1140 (1966).
Henderson, I. C., Lieber, M. M., and Todaro, G. J., Virology, 60, 282–287 (1974).
Todaro, G. J., Benveniste, R. E., Lieber, M. M., and Livingston, D. M., Virology, 55, 506–515 (1973).
Gardner, M. B., et al., J. Am. Vet. Med. Ass., 158, 1046–1053 (1971).
Benveniste, R. E., et al., Nature, 248, 17–20 (1974).
Todaro, G. J., Sherr, C. J., Benveniste, R. E., Lieber, M. M., and Melnick, J. L., Cell, 2, 55–61 (1974).
Starkey, R. H., Cohen, S., and Orth, D. N., Science, 189, 800–802 (1975).
De Larco, J., and Todaro, G. J., Cell, 8, 365–371 (1976).
Nicolson, G. L., Lacorbiere, M., and Eckhart, W., Biochemistry, 14, 172–179 (1975).
Thomopoulos, P., Roth, J., Lovelace, E., and Pastan, I., Cell, 8, 417–424 (1976).
Scolnick, E. M., Howk, R. S., Anisowicz, A., Peebles, P. T., Scher, C. D., and Parks, W. P., Proc. natn. Acad. Sci. U.S.A., 72, 4650–4654 (1975).
Theilen, G. H., Gould, D., Fowler, M., and Dungworth, D. L., J. natn. Cancer Inst., 47, 881–889 (1971).
Todaro, G. J., Nature new Biol., 240, 157–160 (1972).
Del Villano, B. C., Nave, B., Croker, B. P., Lerner, R. A., and Dixon, F. J., J. exp. Med., 141, 172–187 (1975).
Obata, Y., Ikeda, H., Stockert, E., and Boyse, E. A., J. exp. Med., 141, 188–197 (1975).
Tung, J.-S., Vitetta, E. S., Fleissner, E., and Boyse, E. A., J. exp. Med., 141, 198–205 (1975).
Lerner, R. A., Wilson, C. B., Del Villano, B. C., McConahey, P. J., and Dixon, F. J., J. exp. Med., 143, 151–166 (1976).
Gospodarowicz, D., and Moran, J. S., J. Cell Biol., 66, 451–457 (1975).
Holley, R. W., and Kiernan, J. A., Proc. natn. Acad. Sci. U.S.A., 71, 2908–2911 (1974).
Levi-Montalcini, R., Meyer, H., and Hamburger, V., Cancer Res., 14, 49–57 (1954).
Dulak, N. C., and Temin, H. M., J. cell. Physiol., 81, 153–160 (1973).
Smith, G. L., and Temin, H. M., J. cell. Physiol., 84, 181–192 (1974).
Rechler, M. M., Podskalny, J. M., and Nissley, S. P., Nature, 259, 134–136 (1976).
O'Keefe, E., Hollenberg, M. D., and Cuatrecasas, P., Archs Biochem. Biophys., 164, 518–526 (1974).
Carpenter, G., and Cohen, S., J. Cell Biol. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Todaro, G., De Larco, J. & Cohen, S. Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells. Nature 264, 26–31 (1976). https://doi.org/10.1038/264026a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/264026a0
- Springer Nature Limited
This article is cited by
-
TGFβ signaling networks in ovarian cancer progression and plasticity
Clinical & Experimental Metastasis (2021)
-
TGF-α antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo
Gene Therapy (2000)
-
Biodistribution of iodine-125 tyramine transforming growth factor ? antisense oligonucleotide in athymic mice with a human mammary tumour xenograft following intratumoral injection
European Journal of Nuclear Medicine (1996)
-
Effect of transforming growth factor-α on gastric acid secretion in rats and monkeys
Digestive Diseases and Sciences (1994)
-
Transforming growth factor beta and the cell surface in tumor progression
Cancer and Metastasis Reviews (1993)