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Transformation of human lymphocytes by Epstein-Barr virus is inhibited by phosphonoacetic acid

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Abstract

PHOSPHONOACETIC acid (PAA) is an inhibitor of herpes simplex virus and of several other herpes viruses. It acts as a specific inhibitor of two viral DNA polymerases, those of herpes simplex and of Marek's disease (a herpes-induced leukaemia in chickens)1,2. We have used PAA as a probe to investigate the possible existence of a virus-directed DNA polymerase and its role in replication of viral genomes during the transformation and proliferation of normal human peripheral lymphocytes induced by Epstein–Barr virus (EBV), -which is a herpes virus closely associated with the development of several neoplasms in man.

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Authors and Affiliations

  1. Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115

    DAVD THORLEY-LAWSON & JACK L. STROMINGER

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  1. DAVD THORLEY-LAWSON
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  2. JACK L. STROMINGER
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THORLEY-LAWSON, D., STROMINGER, J. Transformation of human lymphocytes by Epstein-Barr virus is inhibited by phosphonoacetic acid. Nature 263, 332–334 (1976). https://doi.org/10.1038/263332a0

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