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Induction of transplantation tolerance using serum as antigen source

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Abstract

IT has been shown that massive doses of allogeneic serum produce the prolongation of renal allograft survival in adult pigs1. Furthermore, alloantigenic activity was demonstrated in human serum by inhibiting certain reactions in vitro2–6; and in some strains of mice, the presence of histocompatibility (H) antigens in the serum could be demonstrated by inhibition of the cytotoxicity of specific alloantisera7.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague, 6, Czechoslovakia

    MILAN HAŠEK, JITKA CHUTNÁ, VLADIMÍR HOLÁŇ & MILOŠ SLÁDEČEK

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  1. MILAN HAŠEK
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  2. JITKA CHUTNÁ
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  3. VLADIMÍR HOLÁŇ
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  4. MILOŠ SLÁDEČEK
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HAŠEK, M., CHUTNÁ, J., HOLÁŇ, V. et al. Induction of transplantation tolerance using serum as antigen source. Nature 262, 295–296 (1976). https://doi.org/10.1038/262295a0

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