Skip to main content

Advertisement

SpringerLink
Log in

Milking gene therapy

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Abstract

Oral administration of an adeno-associated virus vector that encodes the enzyme ß-galactosidase effectively reverses lactose intolerance in rats (pages 1131–1135).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. During, M.J. et al. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nature Med. 4, 1131– 1135 (1998).

    Article  CAS  Google Scholar 

  2. Anderson, W.F. Human gene therapy. Nature 392, 25– 30 (1998).

    Article  CAS  Google Scholar 

  3. Hallek, M. & Wendtner, C.M. Recombinant adeno-associated virus (rAAV) vectors for somatic gene therapy: Recent advances and potential clinical applications. Cytokines & Molecular Therapy 2, 69–79 (1996).

    CAS  Google Scholar 

  4. Linden, R.M. et al. Site-specific integration by adeno-associated virus. PNAS 93, 11288–11294 ( 1996).

    Article  CAS  Google Scholar 

  5. Balague, C. et al. Adeno-associated virus Rep 78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome. J. Virol. 71, 3299–3306 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Conrad, C.K. et al. Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung. Gene Ther. 3, 658–668 (1996).

    CAS  PubMed  Google Scholar 

  7. Cheng, D.Y. et al. In vivo and in vitro gene transfer and expression in rat intestinal epithelial cells by E1-deleted adenoviral vector. Hum. Gene Ther. 8, 755–764 (1997).

    Article  CAS  Google Scholar 

  8. Halbert, C.L. et al. Transduction by adeno-associated virus vectors in the rabbit airway: Efficiency, persistence, and readministration. J. Virol. 71, 5932–5941 ( 1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Sahi, T. Genetics and epidemiology of adult-type hypolactasia. Scand. J. Gastroenterol. Suppl. 202, 7–20 ( 1994).

    Article  CAS  Google Scholar 

  10. Corozza, G.R. et al. Beta-Galactosidase from Aspergillus niger in adult lactose malabsorption: A double-blind crossover study. Aliment. Pharmacol. & Ther. 6, 61–66 (1992).

    Article  Google Scholar 

  11. Lozier, J.N. et al. Gut epithelial cells as targets for gene therapy of haemophilia. Hum. Gene Ther. 8, 14811– 14890 (1997).

    Article  Google Scholar 

  12. Alton, E.W.F.W. & Geddes, D.M. Gene therapy for cystic fibrosis: Steady progress, should do well. Eur. Respir. J. 10, 257–259 ( 1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ion Transport Unit, National Heart and Lung Institute, Emmanuel Kaye Building, London, SW3 6LR, U.K.

    Eric W.F.W. Alton, Uta Griesenbach & Duncan M. Geddes

Authors
  1. Eric W.F.W. Alton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Uta Griesenbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Duncan M. Geddes
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Alton, E., Griesenbach, U. & Geddes, D. Milking gene therapy. Nat Med 4, 1121–1122 (1998). https://doi.org/10.1038/2616

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2616

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation