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Calcium ions regulate cyclic AMP and beating in cultured heart cells

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Abstract

ALTHOUGH the transport of Ca2+ is known to be involved in the control of beating by cultured heart cells, little is known about the regulation of this process. There is evidence that catecholamines affect heart cells through their influence on cyclic AMP1–4. In this way they might affect Ca2+ transport and, as a result, contractility. Our experiments with beating heart cells now suggest that both noradrenaline and Ca2+ control the concentration of cyclic AMP in the cells which, in turn, regulates the utilisation of Ca2+. Addition of noradrenaline or depletion of Ca2+ in the external medium results in cells which beat in a lower concentration of external Ca2+ compared with controls.

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Authors and Affiliations

  1. Laboratory of Nuclear Medicine and Radiation Biology, and Molecular Biology Institute, Department of Biological Chemistry, University of California, Los Angeles, California, 90024

    ISAAC HARARY, JEAN-FRANCOIS RENAUD, ED SATO & GARN A. WALLACE

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  1. ISAAC HARARY
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  2. JEAN-FRANCOIS RENAUD
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  3. ED SATO
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  4. GARN A. WALLACE
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HARARY, I., RENAUD, JF., SATO, E. et al. Calcium ions regulate cyclic AMP and beating in cultured heart cells. Nature 261, 60–61 (1976). https://doi.org/10.1038/261060a0

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  • DOI: https://doi.org/10.1038/261060a0

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