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Intracellular forms of Epstein–Barr virus DNA in human tumour cells in vivo

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Abstract

Tumour biopsies from Burkitt lymphoma patients, as well as human nasopharyngeal carcinoma cells growing in athymic nude mice, contain Epstein–Barr virus DNA as covalently closed circular DNA. In addition, integrated viral DNA sequences seem to be present.

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Author information

Author notes

  1. Christine Kaschka-Dierich

    Present address: Hygiene Institut, Universität Göttingen, West Germany

Authors and Affiliations

  1. Departments of Tumor Biology, Chemistry and Biochemistry, Karolinska Institutet, 104 01, Stockholm, Sweden

    Christine Kaschka-Dierich, Alice Adams, Tomas Lindahl, Georg W. Bornkamm, Gunnar Bjursell & George Klein

  2. Cancer Research Laboratory, St Joseph Hospital, Houston, Texas, 77002

    Beppino C. Giovanella

  3. Department of Head and Neck Surgery, Kenyatta National Hospital, Nairobi, Kenya

    Surjit Singh

  4. On leave from Institut für klinische Virologie, Universität Erlangen-Nürnberg, Erlangen, West Germany

    Georg W. Bornkamm

Authors
  1. Christine Kaschka-Dierich
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  2. Alice Adams
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  3. Tomas Lindahl
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  4. Georg W. Bornkamm
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  5. Gunnar Bjursell
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  6. George Klein
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  7. Beppino C. Giovanella
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  8. Surjit Singh
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Kaschka-Dierich, C., Adams, A., Lindahl, T. et al. Intracellular forms of Epstein–Barr virus DNA in human tumour cells in vivo. Nature 260, 302–306 (1976). https://doi.org/10.1038/260302a0

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  • DOI: https://doi.org/10.1038/260302a0

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