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Selective entry of immunoblasts into gut from intestinal lymph

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Abstract

THE observation1 that the lymphoid blast cells in the thoracic duct lymph of rats homed preferentially to the lamina propria of the small gut after being injected intravenously has received ample confirmation2–4. But although the thoracic duct lymph of rodents comes principally from the intestine there must also be a significant contribution from other viscera as well as from the caudal somatic lymph nodes. It follows that the large lymphoid immuno-blasts present in thoracic duct lymph may have come from several sources, and it has been shown that their numbers increase after antigens have been injected subcutaneously into the hindquarters5. Are the immunoblasts that home to the small gut selected randomly, or do they have some special feature which mediates their extravasation in the gut? Straightforward immunological factors such as the specificity of the immunoblasts or the presence of antigens in the gut do not seem to be of primary importance6,7.

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Authors and Affiliations

  1. Chester Beatty Research Institute, Clifton Avenue, Downs Road, Sutton, Surrey, SM2 5PX, UK

    JOHN HOPKINS & JOSEPH G. HALL

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  1. JOHN HOPKINS
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  2. JOSEPH G. HALL
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HOPKINS, J., HALL, J. Selective entry of immunoblasts into gut from intestinal lymph. Nature 259, 308–309 (1976). https://doi.org/10.1038/259308a0

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  • DOI: https://doi.org/10.1038/259308a0

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