Skip to main content

Advertisement

SpringerLink
Log in

Vertical transmission of tumour resistance in guinea pigs

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

BOTH intact bacillus Calmette–Guerin(BCG)1–3 and the methanol extraction residue (MER) fraction4 of BCG have had extensive application in tumour immunotherapy. Treatment with MER nonspecifically stimulates both the cellular and humoral immune systems4,5, and has been successful in tumour immunotherapy in a number of animal models6,7. Experiments in our laboratories, using animals obtained from the Weizmann Institute, Rehovot, Israel, have shown that about 40% of strain 2 guinea pigs injected with MER or with the supernatant of sonically-disrupted BCG (BCG SS), 1–2 months before intradermal inoculation with 106 cells of the transplantable line 10 hepatocarcinoma8,9, are resistant to the growth of this tumour10. Similarly, injection of MER into developing tumour nodules 7d after tumour cell implantation results in complete tumour regression in approximately 40% of the animals tested (M.A.W., P.M. and D.W.W., unpublished).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Old, L. J., Clarke, D. A., and Benacerraf, B., Nature, 184, 291–292 (1959).

    Article  ADS  Google Scholar 

  2. Mathe, G., Kamel, M., Dezfulian, M., Halle-Pannenko, O., and Bourut, C., Cancer Res., 33, 1987–1997 (1973).

    CAS  PubMed  Google Scholar 

  3. Pimm, M. V., and Baldwin, R. W., Int. J. Cancer, 15, 260–269 (1975).

    Article  CAS  Google Scholar 

  4. Weiss, D. W., Natn. Cancer Inst. Monogr., 35, 157–171 (1972).

    CAS  Google Scholar 

  5. Ben-Efraim, S., Constantini-Sourojon, M., and Weiss, D. W., Cell Immun., 7, 370–379 (1973).

    Article  CAS  Google Scholar 

  6. Haran-Ghera, N., and Weiss, D. W., J. natn. Cancer Inst., 50, 229–234 (1973).

    Article  CAS  Google Scholar 

  7. Hopper, D. G., Pimm, M. V., and Baldwin, R. W., Br. J. Cancer, 31, 176–181 (1975).

    Article  CAS  Google Scholar 

  8. Zbar, B., Bernstein, I., Tanaka, T., and Rapp, H. J., Science, 170, 1217–1218 (1970).

    Article  ADS  CAS  Google Scholar 

  9. Zbar, B., and Tanaka, T., Science, 172, 271–273 (1971).

    Article  ADS  CAS  Google Scholar 

  10. Minden, P., Wainberg, M., and Weiss, D. W., J. natn. Cancer Inst., 52, 1643–1645 (1974).

    Article  CAS  Google Scholar 

  11. Barnes, J. M., J. Path. Bact., 77, 371–380 (1959).

    Article  CAS  Google Scholar 

  12. Minden, P., Sandridge, J., Wainberg, M. A., and McClatchy, J. K., J. natn. Cancer Inst. (in the press).

  13. Meltzer, M. S., Leonard, E. J., Rapp, H. J., and Borsos, T., J. natn. Cancer Inst., 47, 703–709 (1971).

    CAS  Google Scholar 

  14. Brambell, F. W. R., in Transmission of Passive Immunity from Mother to Young, 142–165 (North-Holland, Amsterdam, 1970).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lady Davis Institute for Medical Research, Jewish General Hospital,

    MARK A. WAINBERG

  2. Departement de Microbiologie et Immunologie, Universite de Montreal, Montreal, Canada

    MARK A. WAINBERG

  3. National Jewish Hospital and Research Center, Denver, Colorado

    PERCY MINDEN

  4. Hebrew University-Hadassah Medical School, Jerusalem, Israel

    DAVID W. WEISS

Authors
  1. MARK A. WAINBERG
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. PERCY MINDEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. DAVID W. WEISS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WAINBERG, M., MINDEN, P. & WEISS, D. Vertical transmission of tumour resistance in guinea pigs. Nature 259, 213–215 (1976). https://doi.org/10.1038/259213a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/259213a0

  • Springer Nature Limited

This article is cited by

Search

Navigation