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Persistence of CMV genome in lymphoid cells after congenital infection

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An Erratum to this article was published on 05 February 1976

Abstract

THE persistence in a latent state of the herpes simplex virus in neuronal cells1–3 and of the Epstein–Barr virus (EBV) in lymphoblastoid cells4,5 has been documented. Cytomegaloviruses (CMVs) have been isolated in the past from leukocytes of congenitally infected babies6 and found in peripheral leukocytes by in situ RNA–DNA cytohybridisation (C. H. Huang, P. Neiman and J. S. Pagano, unpublished data). EBV-positive lymphoblastoid cell lines have been established from three of 12 patients with CMV mononucleosis7,8 but the possible persistence of CMVs in these lines was not documented. We have now found an unexpressed CMV genome in an EBV-positive lymphoblastoid cell line.

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Authors and Affiliations

  1. Institute of Microbiology of Montreal and Department of Microbiology and Pediatrics,

    JEAN H. JONCAS

  2. Department of Microbiology and Pediatrics, University of Montreal and St Justine Hospital, Montreal, Quebec, Canada, HN7 423

    JOSÉ MENEZES

  3. Cancer Center Program and Departments of Medicine and Bacteriology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina

    ERIC SHANG HUANG

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  1. JEAN H. JONCAS
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  2. JOSÉ MENEZES
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  3. ERIC SHANG HUANG
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JONCAS, J., MENEZES, J. & HUANG, E. Persistence of CMV genome in lymphoid cells after congenital infection. Nature 258, 432–434 (1975). https://doi.org/10.1038/258432a0

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  • DOI: https://doi.org/10.1038/258432a0

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