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Inhibition of mammalian cytotoxic cells by phosphatidylcholine and its analogue

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Abstract

MUCH interest has focused recently on the elucidation of cytotoxic mechanisms in cellular immunology. In addition to complement-mediated cytolysis, two major cell-mediated reactions have been realised from in vitro studies: the cytotoxic T-cell1,2 and K-cell3,4 systems. The former is characterised by the killing of target cells by cytotoxic T cells taken from donors previously sensitised to target cells, whereas in the latter, target cells are destroyed by normal or unsensitised effectors (K cells), provided IgG antibody to the target cell is present. The exact nature of the K cell is still a matter of controversy5,6. Although a voluminous literature exists, little is known about the actual mechanism(s) of action of cytotoxic lymphoid cells. We describe here experiments which implicate phospholipase A activity as an early step of the kill mechanism in K-cell cytotoxicity.

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Authors and Affiliations

  1. Clinical Immunology and Rheumatic Disease Section, Department of Medicine, University of Southern California School of Medicine, Los Angeles, California, 90033

    L. D. FRYE & G. J. FRIOU

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  1. L. D. FRYE
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  2. G. J. FRIOU
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FRYE, L., FRIOU, G. Inhibition of mammalian cytotoxic cells by phosphatidylcholine and its analogue. Nature 258, 333–335 (1975). https://doi.org/10.1038/258333a0

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