Abstract
THE major histocompatibility complex in the mouse encompasses several distinct loci, which, with one exception, control the expression of cell surface glycoproteins. The exception is the Ss-S1p traits1. The Ss trait involves regulation of the level of a plasma protein, the Ss protein2. The S region of the H–2 complex, whose marker gene controls the Ss-protein concentration, also regulates the haemolytic complement level3. This has led to the suggestion that the Ss protein is a component of complement3,4. We have isolated the Ss protein and demonstrate here that it is the murine equivalent of C4.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Shreffler, D. C., and Passmore, H. C., in Immunogenetics of the H-2 System, 56 (Karger, Basel, 1971).
Sreffler, D. C., and Owen, R. D., Genetics, 48, 9 (1963).
Demant, P., Capkova, J., Hinzova, E., and Voracova, B., Proc. natn. Acad. Sci. U.S.A., 70, 863 (1973).
Hansen, T. H., Shin, H. S., and Shreffler, D. C., J. exp. Med., 141, 1216 (1975).
Müller-Eberhard, H. J., A. Rev. Biochem., 38, 389 (1969).
Herzenberg, L. A., Tachibana, D. K., Herzenberg, L. A., and Rosenberg, L. T., Genetics, 48, 711 (1963).
Ferreira, A., and Nussenzweig, V., J. exp. Med., 141, 513 (1975).
Schreiber, R. D., and Müller-Eberhard, H. J., J. exp. Med., 140, 1324 (1974).
Cooper, N. R., J. exp. Med., 141, 890 (1975).
Müller-Eberhard, H. J. (1974). Prog. Immun., 2, 173 (North Holland, Amsterdam, 1974).
Lachmann, P. J., Grennan, D., Martin, A., and Demant, P., Nature, 258, 242–243 (1975).
Fu, S. M., Kunkel, H. G., Brusman, H. P., Allen, F. H., and Fotino, M., J. exp. Med, 140, 1464 (1974).
Allen, F. H., Vox Sang., 27, 173 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CURMAN, B., ÖSTBERG, L., SANDBERG, L. et al. H–2 linked Ss protein is C4 component of complement. Nature 258, 243–245 (1975). https://doi.org/10.1038/258243a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/258243a0
- Springer Nature Limited
This article is cited by
-
Mouse sip: Female expression due to a dominant non-H-2 gene in wild mice
Immunogenetics (1982)
-
cis-Interacting genes in the S region of the murine major histocompatibility complex
Nature (1981)
-
Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man
Biochemical Genetics (1981)
-
Genetic and structural characterization ofH-2-controlled allelic forms of murine C4
Immunogenetics (1980)
-
Genetic polymorphism of serum complement components in the chimpanzee
Immunogenetics (1980)