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Activity of phasic neurosecretory cells during haemorrhage

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Abstract

APPROXIMATELY 25% of the neurones projecting to the neurohypophysis from the paraventricular (PV) and supraoptic (SO) nuclei of the hypothalamus fire phasically and such a pattern is seldom seen in other hypothalamic cells1. Phasic neurones respond to osmotic stimuli2 but are rarely activated by suckling1,3. It is tempting therefore, to associate these cells with the secretion of vasopressin rather than oxytocin. The functional relationship of their phasic pattern to hormone release, however, remains obscure. We have studied phasic PV neurones during haemorrhage, which releases vasopressin, sometimes with small amounts of oxytocin4. Haemorrhage evoked changes in phasic units over a period long enough for a detailed analysis of their behaviour. Our results show the importance of pattern modulation in phasic neurones and suggest that the mechanism for vasopressin release differs from that described for oxytocin release during suckling1,3.

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Authors and Affiliations

  1. ARC Institute of Animal Physiology, Babraham, Cambridge, CB2 4AT, UK

    J. B. WAKERLEY, D. A. POULAIN, R. E. J. DYBALL & B. A. CROSS

  2. Laboratoire de Neurophysiologie, Faculté de Medecine de l'Universite, Place de la Victoire, Bordeaux, France

    D. A. POULAIN

Authors
  1. J. B. WAKERLEY
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  2. D. A. POULAIN
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  3. R. E. J. DYBALL
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  4. B. A. CROSS
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WAKERLEY, J., POULAIN, D., DYBALL, R. et al. Activity of phasic neurosecretory cells during haemorrhage. Nature 258, 82–84 (1975). https://doi.org/10.1038/258082a0

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  • DOI: https://doi.org/10.1038/258082a0

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