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Latent infection of the peripheral ANS with herpes simplex virus

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Abstract

IN both experimentally infected animals1,2 and in asymptomatic human subjects3,4 herpes simplex virus (HSV) can establish a latent infection in the sensory ganglia of the nervous system. It is probably the periodic reactivation of virus within these ganglia that gives rise to recurrent herpetic eruptions on epithelial surfaces innervated by the infected ganglia. The ganglia of the peripheral autonomic nervous system seem to share a common embryogenesis with sensory ganglia5. Although it has been shown that acute infection of autonomic ganglia with HSV6 and the related herpesvirus, pseudorabies virus7–9, can occur, it has not been established that the peripheral autonomic nervous system (ANS) can support a latent infection with these or other viruses. We report here a marine model of latent infection of the superior cervical ganglion (SCG) of the sympathetic division of the ANS.

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Author notes

  1. RICHARD W. PRICE

    Present address: Division of Neuropsychiatry, Memorial–Sloan Kettering Cancer Center, 444 East 68th Street, New York, New York, 10021

  2. BARRETT J. KATZ

    Present address: Department of Neurology, Children's Hospital Medical Center, 300 Longwood Avenue, Boston, Massachusetts, 02115

Authors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20014

    RICHARD W. PRICE, BARRETT J. KATZ & ABNER LOUIS NOTKINS

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  1. RICHARD W. PRICE
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  2. BARRETT J. KATZ
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  3. ABNER LOUIS NOTKINS
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PRICE, R., KATZ, B. & NOTKINS, A. Latent infection of the peripheral ANS with herpes simplex virus. Nature 257, 686–688 (1975). https://doi.org/10.1038/257686a0

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  • DOI: https://doi.org/10.1038/257686a0

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