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Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line

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Abstract

MACROPHAGES found in lymphoid and other tissues are defined by adherence, staining, morphology and rapid pinocytosis. Subtypes of macrophage-like cells have been distinguished on the basis of density and functional properties1–3. Immune macrophages4 and normal macrophages in the presence of specific antiserum5–8 will lyse relevant target cells, and can phagocytose cells by an independent mechanism9–12, but it has not been shown that the same cell type can carry out both functions.

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Author notes

  1. PETER RALPH

    Present address: Sloan-Kettering Institute for Cancer Research, 145 Boston Post Road, Rye, New York, 10580

Authors and Affiliations

  1. Salk Institute for Biological Studies, PO Box 1809, San Diego, California, 92112

    PETER RALPH & ILONA NAKOINZ

Authors
  1. PETER RALPH
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  2. ILONA NAKOINZ
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RALPH, P., NAKOINZ, I. Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line. Nature 257, 393–394 (1975). https://doi.org/10.1038/257393a0

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  • DOI: https://doi.org/10.1038/257393a0

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