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Enhancement of interferon production by poly(rI)·poly(rC) in mouse cell cultures by ascorbic acid

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Abstract

WE have reported1 an increased response to interferon induction in mice fed a diet containing vitamin C, and have now found a similar phenomenon in vitro. Addition of L-ascorbate to cultures of mouse cells (transformed L cells and normal embryonic fibroblasts) stimulated with polyinosinic acid · polycytidylic acid (poly(rI)·poly(rC)) resulted in increased synthesis of interferon.

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  1. Department of Pathology, University of Oregon Medical School, Portland, Oregon, 97201

    BENJAMIN V. SIEGEL

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  1. BENJAMIN V. SIEGEL
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SIEGEL, B. Enhancement of interferon production by poly(rI)·poly(rC) in mouse cell cultures by ascorbic acid. Nature 254, 531–532 (1975). https://doi.org/10.1038/254531a0

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