Skip to main content
SpringerLink
Log in

Positional signalling and specification of digits in chick limb morphogenesis

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

The interpretation of positional information can provide the basis for pattern formation in limb morphogenesis. The gradient in positional information along the antero–posterior axis, which is specified with respect to a localised boundary region, can be modified by grafting this region to successive positions along the axis. The pattern of digits obtained is consistent with a model based on diffusion of a labile morphogen and is thus similar to models proposed for the development of pattern in invertebrates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wolpert, L., Curr. Top. devl Biol., 6, 183–224 (1972).

    Article  Google Scholar 

  2. Child, C. M., Patterns and Problems of Development (University of Chicago Press, Chicago, 1941).

    Book  Google Scholar 

  3. Lawrence, P. A., Crick, F. H. C., and Munro, M., J. Cell Sci., 11, 815–854 (1972).

    CAS  PubMed  Google Scholar 

  4. Lawrence, P. A., in Developmental Systems: Insects, 2, (edit. by Counce, S. J., and Waddington, C. H.) 157–198 (Academic, London, 1972).

    Google Scholar 

  5. Sander, K., in Ciba Symposium on Cell Patterning, (Associated Scientific, Amsterdam, in the press).

  6. Wolpert, L., Hornbruch, A., and Clarke, M. R. B., Am. Zool., 14, 647–663 (1974).

    Article  Google Scholar 

  7. Wolpert, L., Clark, M. R. B., and Hornbruch, A., Nature, 239, 101–103 (1972).

    Article  ADS  CAS  Google Scholar 

  8. Summerbell, D., Lewis, J. H., and Wolpert, L., Nature, 244, 492–496 (1973).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Wolpert, L., Lewis, J. H., Summerbell, D., in Ciba Symposium on Cell Patterning (Associated Scientific, Amsterdam, in the press).

  10. Summerbell, D., and Lewis, J. H., J. Embryol. exp. Morph., 33 (in the press).

  11. Wolpert, L., J. theor. Biol., 25, 1–47 (1969).

    Article  CAS  PubMed  Google Scholar 

  12. Saunders, J. W., and Gasseling, M. T., in Epithelial-Mesenchymal Interactions (edit. by Fleischmajer, R., and Billingham, R. E.) 78–79 (Williams and Wilkins, Baltimore, 1968).

    Google Scholar 

  13. Saunders, J., Ann. N.Y. Acad. Sci., 193, 29–41 (1972).

    Article  ADS  PubMed  Google Scholar 

  14. Crick, F. H. C., Nature, 225, 420–422 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Summerbell, D., J. Embryol. exp. Morph., 32, 227–237 (1974).

    CAS  PubMed  Google Scholar 

  16. Stark, R. J., and Searls, R. L., Devl Biol., 33, 138–153 (1972).

    Article  Google Scholar 

  17. Summerbell, D., J. Embryol. exp. Morph., 32, 651–660 (1974).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology as Applied to Medicine, The Middlesex Hospital Medical School, London, W1P 6DB, UK

    C. Tickle, D. Summerbell & L. Wolpert

Authors
  1. C. Tickle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Summerbell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Wolpert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tickle, C., Summerbell, D. & Wolpert, L. Positional signalling and specification of digits in chick limb morphogenesis. Nature 254, 199–202 (1975). https://doi.org/10.1038/254199a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/254199a0

  • Springer Nature Limited

This article is cited by

Search

Navigation