Skip to main content
Log in

Reactivity to tumour-associated antigens detected in mice undergoing liver regeneration

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

IN addition to the well-known, individually unique tumour-specific antigens in chemically induced neoplasms and the common ones in neoplasms induced by the same virus, there is evidence that neoplastic cells have antigens which are present in certain normal, syngeneic cells, but which may still be reacted against immunologically1. Most notable has been the demonstration that many tumours share antigens with normal embryonic cells2. Immunity to these antigens can be detected in various ways. It has been shown, for example, that lymphocytes from multiparous mice are cytotoxic to cultivated neoplastic but not to normal adult cells3–5 and that serum from pregnant mice can inhibit (block) this cytotoxic effect4–7.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Hellström, K. E., and Hellström, I., Adv. Immun., 18, 209–277 (1974).

    Article  Google Scholar 

  2. Baldwin, R. W., Adv. Cancer Res., 18, 1–75 (1973).

    Article  CAS  Google Scholar 

  3. Brawn, R. J., Int. J. Cancer, 6, 245–249 (1970).

    Article  CAS  Google Scholar 

  4. Dierlam, P., Anderson, N. G., and Coggin, J. H., Jr, Proc. first Conf. and Workshop Embryonic and Fetal Antigens in Cancer (edit, by Anderson, N. G., and Coggin, J. H., Jr,) 203 (Oak Ridge National Laboratory, 1971).

    Google Scholar 

  5. Baldwin, R. W., and Embleton, M. J., Int. J. Cancer, 13, 433–443 (1974).

    Article  CAS  Google Scholar 

  6. Hellström, I., and Hellström, K. E., Int. J. Cancer (in the press).

  7. Hellström, I., and Hellström, K. E., Int. J. Cancer (in the press).

  8. Higgens, G. M., and Anderson, R. M., Archs Pathol., 12, 186–202 (1931).

    Google Scholar 

  9. Hellström, I., and Hellström, K. E., In Vitro Methods in Cell Mediated Immunity (edit. by Bloom, B. R., and Glade, P. R.), 409 (Academic, New York and London, 1971).

    MATH  Google Scholar 

  10. Hibbs, I. B., Jr, Lambert, L. H., Jr, and Remington, J. S., Nature new Biol., 235, 48 (1972).

    Article  Google Scholar 

  11. Bonney, R. J., Hopkins, H. S., Walker, P. R., and Potter, V. R., Biochem. J., 136, 115–124 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Abelev, G. I., Adv. Cancer Res., 14, 295–358 (1971).

    Article  CAS  Google Scholar 

  13. Prehn, R., and Lappé, M., Transplant. Rev., 7, 26 (1971).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

HELLSTROM, I., HELLSTROM, K. & NISHIOKA, M. Reactivity to tumour-associated antigens detected in mice undergoing liver regeneration. Nature 253, 744–746 (1975). https://doi.org/10.1038/253744a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/253744a0

  • Springer Nature Limited

This article is cited by

Navigation