Abstract
METHYLATION of a specific nucleotide occurs at the initial stage of transcription of the double-stranded RNA genome in cytoplasmic polyhedrosis virus (CPV) in the presence of the methyl-group donor, S-adenosyl methionine (SAM)1. Methylation of mRNA has been reported recently not only for other viruses2,3 but also for a mouse L-cell4. Since methylation seems to be coupled with the initiation of mRNA synthesis in CPV, the structure of the initiation (5′) terminus of mRNA transcribed from CPV by the virus-containing RNA polymerase is of particular interest.
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FURUICHI, Y., MIURA, KI. A blocked structure at the 5′ terminus of mRNA from cytoplasmic polyhedrosis virus. Nature 253, 374–375 (1975). https://doi.org/10.1038/253374a0
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DOI: https://doi.org/10.1038/253374a0
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