Skip to main content
SpringerLink
Log in

Host range of murine xenotropic virus: replication in avian cells

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

AN endogenous C-type virus with an unusual tropism has been isolated from New Zealand Black (NZB) and other mouse strains. Although it has the murine leukaemia virus (MLV) gs-1 antigen and reverse transcriptase, it cannot be propagated in mouse cells. It is only infectious for cells foreign to the host species and has been termed xenotropic1–3. In the course of host range studies, we have discovered that, in contrast to other mammalian C-type viruses, this murine xenotropic virus can cross class barriers and both infect and replicate efficiently in avian cells. In these studies, the NZB pseudotype murine sarcoma virus (MSV) (Table 1) was used as it provides a good marker (focus formation) for NZB virus infection and replication.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Levy, J. A., and Pincus, T., Science, 107, 326–327 (1970).

    Article  ADS  Google Scholar 

  2. Levy, J. A., Science, 182, 1151–1153 (1973).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Levy, J. A., Am. J. clin. Path., 62, 258–280 (1974).

    Article  CAS  PubMed  Google Scholar 

  4. Hartley, J. W., and Rowe, W. P., Proc. natn. Acad. Sci. U.S.A., 55, 780–786 (1966).

    Article  ADS  CAS  Google Scholar 

  5. Duc-Nguyen, H., J. Virol., 2, 643–644 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Parkman, R., Levy, J. A., and Ting, R. C., Science, 168, 387–389 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Levy, J. A., and Rowe, W. P., Virology, 45, 844–847 (1971).

    Article  CAS  PubMed  Google Scholar 

  8. Rowe, W. P., Pugh, W. E., and Hartley, J. W., Virology, 42, 1136–1139 (1970).

    Article  CAS  PubMed  Google Scholar 

  9. Aaronson, S. A., and Todaro, G. J., Nature, 225, 458–459 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Klement, V., Freedman, M. H., McAllister, R. M., Nelson-Rees, W. A., and Huebner, R. J., J. natn. Cancer Inst., 47, 65–73 (1971).

    CAS  Google Scholar 

  11. Aaronson, S. A., Nature, 230, 445–447 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Rhim, J. S., Vernon, M. L., Duh, F. G., and Huebner, R. J., Int. J. Cancer, 12, 734–741 (1973).

    Article  CAS  PubMed  Google Scholar 

  13. Huang, A., Besmer, P., Chu, L., and Baltimore, D., J. Virol., 12, 659–662 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Svoboda, J., and Klement, V., Folia Biol., 9, 403–410 (1963).

    CAS  Google Scholar 

  15. Svoboda, J., Donner, L., and Mach, O., Nature, 248, 503–505 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Research Institute, University of California, San Francisco, California, 94143

    JAY A. LEVY

Authors
  1. JAY A. LEVY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LEVY, J. Host range of murine xenotropic virus: replication in avian cells. Nature 253, 140–142 (1975). https://doi.org/10.1038/253140a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/253140a0

  • Springer Nature Limited

This article is cited by

Search

Navigation