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Temperature-dependent interconversion of histamine H1 and H2 receptors in guinea pig ileum

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Abstract

HISTAMINE receptors mediating changes in gastric secretion are resistant to blockade by most antihistamines1, and this led Ash and Schild2 to propose two classes of receptors, H1 typified by the system in guinea pig ileum or bronchi, and H2 responsible for effects on atria and gastric secretion. This concept is supported by the demonstration that, in contrast to most antihistamines, a series of substituted imidazole compounds are competitive antagonists of the H2 receptor with negligible action on H1 (refs 3, 4).

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References

  1. Loew, E. R., Physiol. Rev., 27, 542–573 (1947).

    Article  CAS  Google Scholar 

  2. Ash, A. S. F., and Schild, H. O., Br. J. Pharmac. Chemother., 27, 427–439 (1966).

    Article  CAS  Google Scholar 

  3. Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R., and Parsons, E. M., Nature, 236, 385–390 (1972).

    Article  ADS  CAS  Google Scholar 

  4. Black, J. W., Duncan, W. A. M., Emmett, J. C., Ganellin, C. R., Hesselbo, T., Parsons, M. E., and Wyllie, J. H., Agents and Actions, 3, 133–137 (1973).

    Article  CAS  Google Scholar 

  5. McNeill, J. H., and Verma, S. C., Can. J. Physiol. Pharmacol., 52, 23–27 (1974).

    Article  CAS  Google Scholar 

  6. Rang, H. P., Br. J. Pharmac. Chemother., 22, 356–365 (1964).

    Article  CAS  Google Scholar 

  7. Trendelenburg, U., J. Pharmac. exp. Ther., 130, 450–460 (1960).

    CAS  Google Scholar 

  8. Kunos, G., and Szentiványi, M., Nature, 217, 1077–1078 (1968).

    Article  ADS  CAS  Google Scholar 

  9. Rosiere, C. E., and Grossman, M. I., Science, 113, 651 (1951).

    Article  ADS  CAS  Google Scholar 

  10. Charnock, J. S., Cook, D. A., and Opit, L. J., Nature new Biol., 233, 171–172 (1971).

    Article  CAS  Google Scholar 

  11. Rocha e Silva, M., Fernandes, F., and Antonio, A., Eur. J. Pharmacol., 25, 231–240 (1974).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada

    T. P. KENAKIN, C. A. KRUEGER & D. A. COOK

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  1. T. P. KENAKIN
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  2. C. A. KRUEGER
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  3. D. A. COOK
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KENAKIN, T., KRUEGER, C. & COOK, D. Temperature-dependent interconversion of histamine H1 and H2 receptors in guinea pig ileum. Nature 252, 54–55 (1974). https://doi.org/10.1038/252054a0

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  • DOI: https://doi.org/10.1038/252054a0

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