Abstract
The structure of a tRNA has been determined by isomorphous replacement. Some of the interactions which maintain the tertiary structure are of a novel type. Our model differs significantly from one which has recently been proposed.
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References
Clark, B. F. C., Doctor, B. P., Holmes, K. C., Klug, A., Marcker, K. A., Morris, S. J., and Paradies, H. H., Nature, 219, 1222–1224 (1968).
Brown, R. S., Clark, B. F. C., Coulson, R. R., Finch, J. T., Klug, A., and Rhodes, D., Eur. J. Biochem., 31, 130–134 (1972).
Ladner, J. E., Finch, J. T., Klug, A., and Clark, B. F. C., J. molec. Biol., 72, 99–101 (1972).
Suddath, F. L., Quigley, G. J., McPherson, A., Sneden, D., Kim, J. J., Kim, S. H., and Rich, A., Nature, 248, 20–24 (1974).
Marsh, D. J., and Petsko, G. A., J. Appl. Cryst., 6, 76–80 (1973).
Richards, F. M., J. molec. Biol., 37, 225–230 (1968).
Rubin, J., Brennan, T., and Sundaralingam, M., Biochemistry, 11, 3112–3128 (1972).
Kim, S. H., Berman, H. M., Seeman, N. C., and Newton, M. D., Acta Cryst., B 29, 703–710 (1973).
Fresco, J. R., Adams, A., Ascione, R., Henley, D., and Lindahl, T., Cold Spring Harb. Symp. quant. Biol., 31, 527–537 (1966).
Levitt, M., in Polymerisation in Biological Systems (edit. by Wolstenholme, G. E. W., and O'Connor, M.), 147–171 (Elsevier, Amsterdam, 1972).
Arnott, S., Progress in Biophysics and Molecular Biology, 21 (edit. by Butler, J. A. V., and Noble, D.), 265–319 (Pergamon Press, Oxford, 1970).
Rich, A., Davies, D. R., Crick, F. H. C., and Watson, J. D., J. molec. Biol., 3, 71–86 (1961).
Hoogsteen, K., Acta Cryst., 12, 822–823 (1959).
Yaniv, M., Favre, A., and Barrell, B. G., Nature, 223, 1331–1333 (1969).
Levitt, M., Nature, 224, 759–763 (1969).
Brown, D. M., in Basic Principles in Nucleic Acid Chemistry (edit. by Ts'O, P. O. P.), 2, chapter 1 (Academic Press, London, 1974).
Fuller, W., and Hodgson, A., Nature, 215, 817–821 (1967).
Levitt, M., J. molec. Biol., 80, 255–263 (1973).
Woese, C., Nature, 226, 817–820 (1970).
Hill, C. W., Combriato, G., Steinhart, W., Riddle, D. L., and Carbon, J., J. biol. Chem., 248, 4252–4262 (1973).
Holley, R. W., Apgar, J., Everett, G. A., Madison, J. T., Marquisee, M., Merrill, S. H., Penswick, J. R., and Zamir, A., Science, 147, 1462–1465 (1965).
Barrell, B. G., and Clark, B. F. C., Handbook of Nucleic Acid Sequences (Joynson–Bruvvers, Oxford, 1974).
Schevitz, R. W., Navia, M. A., Bantz, D. A., Cornick, G., Rosa, J. J., Rosa, M. D. H., and Sigler, P. B., Science, 177, 429–431 (1972).
Kim, S. H., Ouigley, G., Suddath, F. L., McPherson, A., Sneden, D., Kim, J. J., Weinzierl, J., Blattmann, P., and Rich, A., Proc. natn. Acad. Sci. U.S.A., 69, 3746–3750 (1972).
Klug, A., Robertus, J. D., Ladner, J. E., Brown, R. S., Finch, J. T., Proc. natn. Acad. Sci. U.S.A. (in the press).
Robertus, J. D., Ladner, J. E., Finch, J. T., Rhodes, D., Brown, R. S., Clark, B. F. C., and Klug, A., Nucleic Acids Res., 1, 927–932 (1974).
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Robertus, J., Ladner, J., Finch, J. et al. Structure of yeast phenylalanine tRNA at 3 Å resolution. Nature 250, 546–551 (1974). https://doi.org/10.1038/250546a0
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DOI: https://doi.org/10.1038/250546a0
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