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Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins

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Abstract

THE spin lattice relaxation time (T1) is the exponential time constant for re-equilibration of nuclear spins with their surroundings (the lattice) following resonance excitation, and is consequently related to the correlation time of the nuclei in solution. Thus, the determination of T1 values would be of interest in many biological systems. Measurement of the relative motility of different portions of a protein molecule, for example, could shed light on conformational and functional properties.

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Authors and Affiliations

  1. Laboratory of Chemical Physics, National Institute of Arthritis, Metabolism and Digestive Diseases,

    RODERICK E. WASYLISHEN

  2. Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20014

    JACK S. COHEN

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  1. RODERICK E. WASYLISHEN
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WASYLISHEN, R., COHEN, J. Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins. Nature 249, 847–850 (1974). https://doi.org/10.1038/249847a0

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  • DOI: https://doi.org/10.1038/249847a0

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