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Effect of ATP on release of intracellular enzymes from damaged cells

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Abstract

THE use of serum enzyme measurements as aids to the diagnosis of disorders of the heart, liver and other organs is established practice in clinical laboratories everywhere, but little is known of the mechanisms whereby intracellular enzymes are discharged from damaged cells. In necrotic states, complete disruption of the cell will lead to release of its contents, but in reversible inflammatory states the cause of the increased membrane permeability remains obscure.

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Authors and Affiliations

  1. Department of Chemical Pathology, Charing Cross Hospital Medical School, Fulham Palace Road, London, W6 8RF, UK

    J. H. WILKINSON & JEAN M. ROBINSON

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  1. J. H. WILKINSON
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  2. JEAN M. ROBINSON
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WILKINSON, J., ROBINSON, J. Effect of ATP on release of intracellular enzymes from damaged cells. Nature 249, 662–663 (1974). https://doi.org/10.1038/249662a0

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  • DOI: https://doi.org/10.1038/249662a0

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