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Incorporation of exogenous DNA into mammalian chromosomes

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Abstract

MANY reports1–4 have shown that exogenous DNA can be taken up and incorporated into the nuclei of cells in culture as well as in vivo; but no morphological evidence has been presented to suggest that such foreign DNA actually becomes associated with the chromosomes of inoculated cells. The Indian barking deer, Muntiacus muntjak, has the lowest number of chromosomes yet reported for mammals, ♀ = 6; ♂ = 7 (ref. 5). The combination of such a low chromosome number and the unique morphology of each pair of chromosomes in the diploid set make this animal particularly attractive for comparative cytogenetic studies. The C- and G-banding patterns6–8 have also been established for this animal which allow even more detailed comparisons to be made than those based solely on gross chromosome morphology.

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Authors and Affiliations

  1. Division of Pathology, Bureau of Biologics, Food and Drug Administration, Rockville, Maryland, 20852

    JOHN C. PETRICCIANI & ROSALYN M. PATTERSON

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  1. JOHN C. PETRICCIANI
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  2. ROSALYN M. PATTERSON
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PETRICCIANI, J., PATTERSON, R. Incorporation of exogenous DNA into mammalian chromosomes. Nature 249, 649–650 (1974). https://doi.org/10.1038/249649a0

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  • DOI: https://doi.org/10.1038/249649a0

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