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Mutagenicity of amino acid analogues in eukaryotes

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Abstract

A LOSS of fidelity in DNA replication and repair enzymes in both pro and eukaryotes, is often expressed as a mutation. Examples of this are shown in the mutator gene activity of a DNA polymerase mutant of T4 (ref. 1) and mutants with increased ultraviolet sensitivity or decreased recombination2–4. Springgate and Loeb5 have reported the altered fidelity of the DNA polymerase of acute lymphatic leukaemia cells.

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References

  1. Speyer, J. F., Biochem. biophys. Res. Commun., 21, 6 (1965).

    Article  CAS  Google Scholar 

  2. Böhme, H., Biochem. biophys. Res. Commun., 28, 191 (1967).

    Article  Google Scholar 

  3. Jyssum, K., J. Bact., 95, 165 (1968).

    Google Scholar 

  4. von Borstel, R. C., Graham, D. E., La Brot, K. J., and Resnick, M. A., Genetics, 60, 233 (1968).

    Google Scholar 

  5. Springgate, C. F., and Loeb, L. A., Proc. nat. Acad. Sci., U.S.A., 70, 245 (1973).

    Article  ADS  CAS  Google Scholar 

  6. Janacek, J., and Rickenberg, H. V., Biochim. biophys. Acta., 81, 108 (1964).

    Google Scholar 

  7. Janacek, J., Folia microbiol., Praha. 12, 132 (1967).

    Article  Google Scholar 

  8. Spizek, J., and Janacek, J., Folia microbiol., Praha. 14, 521 (1969).

    Article  CAS  Google Scholar 

  9. Janacek, J., and Spizek, J., Folia microbiol. Praha. 14, 529 (1969).

    Article  Google Scholar 

  10. Langridge, J., J. Bact., 96, 1711 (1968).

    CAS  PubMed  Google Scholar 

  11. Talmud, P. J., and Lewis, D., Heredity, 31, 139 (1973).

    Google Scholar 

  12. Talmud, P. J., and Lewis, D., Genet. Res., (in the press).

  13. McBride, A. C., and Gowan, C. S., Genet. Res., 14, 121 (1969).

    Article  CAS  Google Scholar 

  14. Lewis, C. M., and Tarrant, G. M., Mutat. Res., 12, 349 (1971).

    Article  CAS  Google Scholar 

  15. Peterkovsky, A., in Transmethylation and methionine biosynthesis (edit. by Shapiro, S. K., and Shlenk, F.) 137, (University of Chicago Press, Chicago, 1965).

    Google Scholar 

  16. Rowbury, R. J., Int. J. radiat. Biol., 21, 297 (1972).

    CAS  Google Scholar 

  17. Wintersberger, E., Biochem. biophys. Res. Commun., 25, 1 (1966).

    Article  CAS  Google Scholar 

  18. Wilkie, D., J. molec. Biol., 47, 107 (1969).

    Article  Google Scholar 

  19. Pardee, A. B., and Prestidge, L. S., J. Bact., 71, 677 (1956).

    CAS  PubMed  Google Scholar 

  20. Day, A. W., and Jones, J. K., Genet. Res., 18, 299 (1971).

    Article  CAS  Google Scholar 

  21. Strømnaes, O., Hereditas, 59, 197 (1968).

    Article  Google Scholar 

  22. Hare, J. D., J. cell. Physiol., 75, 129 (1970).

    Article  CAS  Google Scholar 

  23. Armendares, S., Salamanca, F., and Frenk, S., Nature, 232, 271 (1971).

    Article  ADS  CAS  Google Scholar 

  24. Kondo, S., Jap. J. Genet., 39, 179 (1964).

    Article  Google Scholar 

  25. Zettenberg, G., Mutat. Res., 3, 393 (1966).

    Article  Google Scholar 

  26. Zettenberg, G., Hereditas, 68, 245 (1971).

    Article  Google Scholar 

  27. Vaharu, T., Genetics, 46, 247 (1961).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. George, D. L., and Wilkin, E. M., Genetics, 74, 91 (1973).

    Google Scholar 

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Authors and Affiliations

  1. Department of Botany and Microbiology, University College, London, WC1, UK

    PHILIPPA TALMUD & D. LEWIS

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  1. PHILIPPA TALMUD
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  2. D. LEWIS
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TALMUD, P., LEWIS, D. Mutagenicity of amino acid analogues in eukaryotes. Nature 249, 563–564 (1974). https://doi.org/10.1038/249563a0

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