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Stability of the nucleoside composition of tRNA during biological ageing of mice and mosquitoes

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Abstract

IN several organisms, alterations in tRNA have been reported to occur during physiological changes. Both qualitative and quantitative changes have been demonstrated in isoaccepting species of various tRNAs1–4. Chromatographic changes have often been attributed tc changes in nucleoside composition. In Drosophila, changes in the chromatographic patterns of certain tRNA species at different developmental stages have been correlated with an enzymatic alteration producing a minor nucleoside, Q4. Such differences could be involved in control of protein synthesis at the translational level directly by tRNA species, and (or) in regulation of protein activity by interaction of tRNA with a previously formed protein5,6.

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Authors and Affiliations

  1. Department of Biochemistry, University of Louisville School of Medicine, Health Sciences Center, Louisville, Kentucky, 40201

    JERALD L. HOFFMAN & MARTHA T. MCCOY

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  1. JERALD L. HOFFMAN
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  2. MARTHA T. MCCOY
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HOFFMAN, J., MCCOY, M. Stability of the nucleoside composition of tRNA during biological ageing of mice and mosquitoes. Nature 249, 558–559 (1974). https://doi.org/10.1038/249558a0

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  • DOI: https://doi.org/10.1038/249558a0

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