Skip to main content
SpringerLink
Log in

Molecular basis of control of mitotic cell division in eukaryotes

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

MITOTIC division in Physarum polycephalum is preceded by a marked increase in the phosphate content of very lysine-rich histone (Pp. F1) (ref. 1) due to phosphorylation of serine residues probably at specific points in the amino acid sequence2,3. The phosphate content of F1 histone has been measured by a number of groups under a variety of conditions in an attempt to understand the role of F1 phosphorylation and three facts have been established.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bradbury, E. M., Inglis, R.J., Matthews, H. R., and Sarner, N., Eur. J. Biochem., 33, 131 (1973).

    Article  CAS  Google Scholar 

  2. Langan, T.A., Ann. N.Y. Acad. Sci., 185, 166 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Dixon, G. H., Louie, A. J., McLeod, A. R., and Sing, M. T., Trans. Biochem. Soc. (in the press).

  4. Panyim, S., and Chalkley, R., Biochemistry, 8, 3972 (1969).

    Article  CAS  Google Scholar 

  5. Oliver, D., Balhorn, R., Granner, D., and Chalkley, R., Biochemistry, 11, 3921 (1972).

    Article  CAS  Google Scholar 

  6. Balhorn, R., Chalkley, R., and Granner, D., Biochemistry, 11, 1094 (1972).

    Article  CAS  Google Scholar 

  7. Balhorn, R., Riecke, O., and Chalkley, R., Biochemistry, 10, 3952 (1971).

    Article  CAS  Google Scholar 

  8. Balhorn, R., Balhorn, M., Morris, H. P., and Chalkley, R., Cancer Res., 32, 1775 (1972).

    CAS  Google Scholar 

  9. Stevely, W. S., and Stocken, L. A., Biochem. J., 110, 187 (1968).

    Article  CAS  Google Scholar 

  10. Balhorn, R., Bordwell, J., Sellers, L., Granner, D., and Chalkley, R., Biochem. biophys. Res. Commun., 46, 1326 (1972).

    Article  CAS  Google Scholar 

  11. Gurley, L. R., Walters, R. A., and Tobey, R. A., Biochem. biophys. Res. Commun., 50, 744 (1973).

    Article  CAS  Google Scholar 

  12. Balhorn, R., Tanphaichitr, N., Chalkley, R., and Granner, D.K., Biochemistry, 12, 5146 (1973).

    Article  CAS  Google Scholar 

  13. Marks, D.B., Paik, W. K., and Borun, T. W., J. biol. Chem., 248, 5600 (1973).

    Google Scholar 

  14. Gurley, L. R., Walters, R. A., and Tobey, R. A., J. Cell. Biol. (in the press).

  15. Lake, R. S., and Salzman, N. P., Biochemistry, 11, 4817 (1972).

    Article  CAS  Google Scholar 

  16. Lake, R. S., Nature new Biol., 242, 145 (1973).

    Article  CAS  Google Scholar 

  17. Bradbury, E. M., Inglis, R. J., and Matthews, H. R., Nature, 247, 257 (1974).

    Article  ADS  CAS  Google Scholar 

  18. Lake, R. S., J.Cell Biol., 58, 317 (1973).

    Article  CAS  Google Scholar 

  19. Oppenheim, A., and Katzir, N., Expl Cell Res., 68, 224 (1971).

    Article  CAS  Google Scholar 

  20. Inglis, R. J., thesis, Univ. London (1974).

  21. Bradbury, E. M., Carpenter, B. G., and Rattle, H. W. E., Nature, 241, 123 (1973).

    Article  ADS  CAS  Google Scholar 

  22. Chin, B., Friedrich, P. D., and Bernstein, I. A., J. gen. Microbiol., 71, 93 (1972).

    Article  CAS  Google Scholar 

  23. Sachsenmaier, W., Remy, U., and Plattner-Schoebel, R., Expl Cell Res., 73, 41 (1972).

    Article  CAS  Google Scholar 

  24. Brewer, E. N., and Rusch, H. P., Expl Cell Res., 49, 79 (1968).

    Article  CAS  Google Scholar 

  25. Mohberg, J., and Rusch, H. P., Archs Biochem. Biophys., 138, 418 (1970).

    Article  CAS  Google Scholar 

  26. Rusch, H. P., Adv. Cell Biol., 1, 297 (1971).

    Google Scholar 

  27. Guttes, E., and Guttes, S., in Methods in Cell Physiology (edit. by Prescott, D. M.) 43 (Academic Press, New York, 1964).

    Google Scholar 

  28. Daniel, J. W., and Baldwin, H. H., in Methods in Cell Physiology. (edit. by Prescott, D. M.) 9 (Academic Press, New York, 1964).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biophysics Laboratories, Portsmouth Polytechnic, Gun House, Hampshire Terrace, Portsmouth, UK

    E. M. BRADBURY, R. J. INGLIS & H. R. MATTHEWS

  2. Department of Pharmacology, University of Colorado, School of Medicine, 4200 East 9th Avenue, Denver, Colorado, 80220

    T. A. LANGAN

Authors
  1. E. M. BRADBURY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. J. INGLIS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. R. MATTHEWS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. A. LANGAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRADBURY, E., INGLIS, R., MATTHEWS, H. et al. Molecular basis of control of mitotic cell division in eukaryotes. Nature 249, 553–556 (1974). https://doi.org/10.1038/249553a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/249553a0

  • Springer Nature Limited

This article is cited by

Search

Navigation