Abstract
Mutants in a tRNA methylase gene, supK, of Salmonella typhimurium give suppression of UGA and certain frameshift mutants. In addition suppressors which do not suppress UGA, but which suppress frameshift mutants of opposite (effective) signs are described.
Similar content being viewed by others
References
Brenner, S., Barnett, L., Crick, F. H. C., and Orgel, A., J. molec. Biol., 3, 121–124 (1961).
Crick, F. H. C., Barnett, L., Brenner, S., and Watts-Tobin, R. J., Nature, 192, 1227–1232 (1961).
Terzaghi, E., Okada, Y., Streisinger, G., Emrich, J. Inouye, M., and Tsugita, A., Proc. natn. Acad. Sci. U.S.A., 56, 500–507 (1966).
Barnett, L., Brenner, S., Crick, F. H. C., Shulman, R. G., and Watts-Tobin, R. J., Phil. Trans. R. Soc. Lond., B 252, 487–560 (1967).
Laux, B., Dennis, D., and White, H. B., Biochem. biophys. Res. Commun., 54, 894–898 (1973).
Ames, B. N., Durston, W. E., Yamasaki, E., and Lee, F. D., Proc. natn. Acad. Sci. U.S.A., 70, 2281–2285 (1973).
Riyasaty, S., and Atkins, J. F., J. molec. Biol., 34, 541–557 (1968).
Yourno, J., and Heath, S., J. Bact., 100, 460–468 (1969).
Riddle, D. L., and Roth, J. R., J. molec. Biol., 54, 131–144 (1970).
Smith, J. D., A. Rev. Genet., 6, 235–256 (1973).
Hartman, P. E., and Roth, J. R., Adv. Genet., 17, 1–105 (1973).
Yourno, J., and Kohno, T., Science, 175, 650–652 (1972).
Yourno, J., Nature new Biol., 239, 219–221 (1972).
Yourno, J., and Tanemura, S., Nature, 225, 422–426 (1970).
Riddle, D. L., and Roth, J. R., J. molec. Biol., 66, 495–506 (1972).
Riddle, D. L., and Carbon, J., Nature new Biol., 242, 230–234 (1973).
Atkins, J. F., Elseviers, D., and Gorini, L., Proc. natn. Acad. Sci. U.S.A., 69, 1192–1195 (1972).
Reeves, R. H., and Roth, J. R., J. molec. Biol., 56, 523–533 (1971).
Oeschger, N. S., and Hartman, P. E., J. Bact., 101, 490–504 (1970).
Yourno, J., J. molec. Biol., 48, 437–442 (1970).
Whitfield, H. J., jun., Martin, R. G., and Ames, B. N., J. molec. Biol., 21, 335–355 (1966).
Riddle, D. L., and Roth, J. R., J. molec. Biol., 66, 483–493 (1972).
Smith, H. O., and Levine, M., Virology, 31, 207–216 (1967).
Apirion, D., Phillips, S. L., and Schlessinger, D., Cold Spring Harbor Symp. quant. Biol., 34, 117–128 (1969).
Ganoza, M. C., Vandermeer, J., Debreceni, N., and Phillips, S. L., Proc. natn. Acad. Sci. U.S.A., 70, 31–35 (1973).
Apte, B. N., and Zipser, D., Proc. natn. Acad. Sci. U.S.A., 70, 2969–2973 (1973).
Miller, C. G., and Roth, J. R., J. molec. Biol., 59, 63–75 (1971).
Greeb, J., Atkins, J. F., and Loper, J.C., J. Bact., 106, 421–431 (1971).
Nishimura, S., Prog. Nucleic Acid Res. molec. Biol., 12, 49–85 (1972).
Furuichi, Y., and Ukita, T., Biochem. biophys. Res. Commun., 41, 797–803 (1970).
Eisinger, J., and Spahr, P.-F., J. molec. Biol., 73, 131–137 (1973).
Uhlenbeck, O. C., J. molec. Biol., 65, 25–41 (1972).
Hirsh, D., J. molec. Biol., 58, 439–458 (1971).
Model, P., Webster, R. E., and Zinder, N. D., J. molec. Biol., 43, 177–190 (1969).
Roth, J. R., J. Bact., 102, 467–475 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Atkins, J., Ryce, S. UGA and non-triplet suppressor reading of the genetic code. Nature 249, 527–530 (1974). https://doi.org/10.1038/249527a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/249527a0
- Springer Nature Limited
This article is cited by
-
Helix 69 in 23S rRNA modulates decoding by wild type and suppressor tRNAs
Molecular Genetics and Genomics (2009)
-
Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal ΔA1916 mutation in the 23S rRNA of Escherichia coli
Molecular Genetics and Genomics (2007)
-
Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code
Nature (1983)
-
Mechanism of ribosome frameshifting during translation of the genetic code
Nature (1983)
-
Nucleotide modification of tRNA in. the yeast Saccharomyces cerevisiae is not Affected by the ? factor which modulates suppression efficiency
Current Genetics (1981)