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Type-specific protein in herpes simplex virus envelope reacts with neutralising antibody

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Abstract

CERVICAL carcinoma has been correlated with previous infection with herpes simplex virus type 2 detected serologically1–3. These tests have, however, been confused by the fact that type 1 and type 2 herpes simplex viruses cross neutralise and it is therefore difficult to use the data to provide clear evidence for previous type 2 infection4. We have previously shown that antisera to types 1 and 2 viruses contain antibodies to a structural antigen, Band II (ref. 5), which neutralise both types of virus6. By indirect absorption methods, we have shown that they also contain antibodies to type-specific proteins which neutralise the homologous type only6.

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Author notes

  1. K. L. POWELL

    Present address: Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas, 77025

Authors and Affiliations

  1. Department of Virology, Medical School, Birmingham, B15 2TJ

    K. L. POWELL, A. BUCHAN & CAROLINE SIM

  2. Department of Microbiology, School of Medicine, Leeds, LS2 9NL

    D. H. WATSON

Authors
  1. K. L. POWELL
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  2. A. BUCHAN
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  3. CAROLINE SIM
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  4. D. H. WATSON
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POWELL, K., BUCHAN, A., SIM, C. et al. Type-specific protein in herpes simplex virus envelope reacts with neutralising antibody. Nature 249, 360–361 (1974). https://doi.org/10.1038/249360a0

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