Abstract
INTEREST in the regulation of the immune response to nucleic acids stems largely from the spontaneous occurrence of anti-nucleic acid antibodies in the sera of patients with systemic lupus erythematosus1–4. Genetic factors seem to play a role in this disease, which is associated with certain human transplantation antigens5. Spontaneous production of antibodies to different forms of nucleic acids has been observed in some mouse strains, and is suggested to be correlated with autoimmune diseases1–4,6–8. It is of interest to find out whether the response potential of different mouse strains to nucleic acids, on active immunisation, is related to the spontaneous occurrence of antibodies and/or to autoimmune-like diseases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Thoburn, R., Koffler, D., and Kunkel, H. G., Proc. Soc. exp. Biol. Med., 136, 711–714 (1971).
Levine, L., and Stollar, B. D., Prog. Allergy, 12, 161–191 (1968).
Koffler, D., Carr, R., Agnello, V., Thoburn, R., and Kunkel, H. G., J. exp. Med., 134, 294–312 (1971).
Steinberg, A. D., Baron, S., and Talal, N., Proc. natn. Acad. Sci. U.S.A., 63, 1102–1107 (1969).
Grumet, F. C., Coukell, A., Bodmer, J. G., Bodmer, W. F., and McDevitt, H. O., New Engl. J. Med., 285, 193–196 (1971).
Norin, L. C., and Holmes, M. C., J. Immun., 93, 148–154 (1964).
Ben-Yaakov, M., and Haran-Ghera, N., Israel J. med. Sci., 8, 666 (1972).
Teague, P. O., Friou, G. J., and Myers, L. L., J. Immun., 101, 791–798 (1968).
Stollar, B. D., Fuchs, S., and Mozes, E., J. Immun., 111, 121–129 (1973).
Murphy, E. D., 37th A. Rep., 33 (The Jackson Laboratory, Bar Harbor, Maine, 1964–65).
Wanebo, H. J., Gallmeier, W. M., Boyse, E. A., and Old, L. I., Science, 154, 901–903 (1966).
Stimpfling, J. H., Transplant. Bull., 27, 109–111 (1961).
Maron, E., Scher, H. I., Mozes, E., Arnon, R., and Sela, M., J. Immun., 111, 101–105 (1973).
Stimpfling, J. H., Boyse, E. A., and Mishell, R., Meth. med. Res., 10, 18–21 (1964).
Scher, I., Frantz, M. M., and Steinberg, A. D., J. Immun., 110, 1396–1401 (1973).
Steinberg, A. D., Law, L. W., and Talal, N., Arthritis Rheum., 13, 369–377 (1970).
Amsbaugh, D. F., Hansen, C. T., Prescott, B., Stashak, P. W., Barthold, D. R., and Baker, P. J., J. exp. Med., 136, 931–949 (1972).
Green, I., Paul, W. E., and Benacerraf, B., J. exp. Med., 123, 859–879 (1966).
McDevitt, H. O., J. Immun., 100, 485–492 (1968).
Mackay, I. R., and Burnet, F. M., Autoimmune Diseases, 71–104 (Thomas, Springfield, Illinois, 1963).
Christian, C. L., in Immunological Diseases, (edit. by Samter, M., and Alexander, H. L.) 725–736 (J. and A. Churchill, London, 1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MOZES, E., FUCHS, S. Linkage between immune response potential to DNA and X chromosome. Nature 249, 167–168 (1974). https://doi.org/10.1038/249167a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/249167a0
- Springer Nature Limited
This article is cited by
-
Klinefelter's syndrome and rheumatoid arthritis report of a case and review of the literature
Clinical Rheumatology (1994)
-
Sex differences in formation of anti-T-cell antibodies
Nature (1976)
-
Expression of immune response (Ir) genes in T and B cells
Immunogenetics (1975)
-
Genetic control of the immune response to a thymus independent synthetic polypeptide
Immunogenetics (1974)