Abstract
THE advantages of heterozygotes is one of the most frequent explanations of the maintenance of a polymorphism. This advantage may have the form of a lower fitness of all homozygotes, whatever the allele they possess. According to observations on a small Tuareg isolate, such is apparently the case for the polymorphism of the histocompatibility system HL-A.
Similar content being viewed by others
References
Svejgaard, A., Bratlie, A., Hedin, P. J., Hogman, C., Jersild, C., Kissmeyer-Nielsen, F., Lindlom, B., Sandburg, L., Lindolm, A., Low, B., Messeter, L., Moller, E., Stajbnielsen, L., and Thorsby, E., Tissue Antigens, 1, 81 (1971).
Chaventre, A., thesis, Univ. Paris V (1973).
Jacquard, A., The genetic structure of populations, (Springer Verlag, New York, 1973).
Colombani, J., Degos, L., Petrignani, C., Chaventre, A., Lefevre-Witier, P., and Jacquard, A., in Histocompatibility testing (1972), 153 (Munksgaard, Copenhagen, 1973).
Degos, L., Population, 28, (in the press).
Clarke, B., and Kirby, D. R. S., Nature, 211, 999 (1966).
Fellous, M., and Dausset, J., Nature, 225, 191 (1971).
Mattiuz, P., Ihde, D., Piazza, A., Ceppellini, R., and Bodmer, W. F., in Histocompatibility testing (1970), 193 (Munksgaard, Copenhagen, 1970).
Dausset, J., Degos, L., Fellous, M., and Legrand, L., Genetics (in the press).
Dausset, J., Sasportes, M., and Lebrun, A., Transplant. Proc. (in the press).
Bodmer, J. G., Nevo, S., Bodmer, W. F., and Coukell, A., in Histocompatibility testing (1972), 117 (Munksgaard, Copenhagen, 1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DEGOS, L., COLOMBANI, J., CHAVENTRE, A. et al. Selective pressure on HL-A polymorphism. Nature 249, 62–63 (1974). https://doi.org/10.1038/249062a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/249062a0
- Springer Nature Limited