Skip to main content
SpringerLink
Log in

Novel human serum protein from fibroblast plasma membrane

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

CELL surface components play a major role in the control of normal cell interactions and in the altered growth control and antigenic properties of malignant cells1. To characterise tissue-specific cell surface proteins we undertook an immunochemical study of the material released from cells by mild proteolytic treatment. Our studies have disclosed a fibroblast-specific cell surface and serum antigen in chicken2. The amount of this antigen is greatly reduced in chicken fibroblasts transformed by Rous sarcoma virus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Burger, M. M., Current Topics in Cellular Regulation, 3, 135 (1972).

    Article  Google Scholar 

  2. Ruoslahti, E., Vaheri, A., Kuusela, P., and Linder, E., Biochim. biophys. Acta, 322, 352 (1973).

    Article  CAS  Google Scholar 

  3. Hayflick, L., and Moorhead, P. S., Expl Cell Res., 25, 585 (1961).

    Article  CAS  Google Scholar 

  4. Jacobs, J. P., Jones, C. M., and Baille, J. P., Nature, 227, 168 (1970).

    Article  ADS  CAS  Google Scholar 

  5. Hubbard, A. L., and Cohn, Z. A., J. Cell Biol., 55, 390 (1972).

    Article  CAS  Google Scholar 

  6. Martin, R. G., and Ames, B. N., J. biol. Chem., 236, 1372 (1961).

    CAS  Google Scholar 

  7. Ruoslahti, E., and Seppälä, M., Int. J. Cancer, 8, 374 (1971).

    Article  CAS  Google Scholar 

  8. Charlton, R. K., and Zmijewski, C. M., Science, 170, 636 (1970).

    Article  ADS  CAS  Google Scholar 

  9. Thompson, D. M. P., Krupey, J., Freedman, S. O., and Gold, P., Proc. natn. Acad. Sci. U.S.A., 64, 161 (1969).

    Article  ADS  Google Scholar 

  10. Sjögren, H. O., Hellström, I., Bansal, S. C., and Hell-ström, K. E., Proc. natn. Acad. Sci. U.S.A., 68, 1372 (1971).

    Article  ADS  Google Scholar 

  11. Houck, J. C., Weil, R. L., and Sharma, V. K., Nature new Biol., 240, 210 (1972).

    Article  CAS  Google Scholar 

  12. Hellström, I., and Hellström, K. E., Nature, 240, 471 (1972).

    Article  ADS  Google Scholar 

  13. Moscona, A. A., J. cell. comp Physiol., supplement 1, 60, (1962).

  14. Garrod, D. R., and Steinberg, M. S., Nature, 244, 568 (1973).

    Article  ADS  CAS  Google Scholar 

  15. Goldschneider, I., and Moscona, A. A., J. Cell Biol., 53, 435 (1972).

    Article  CAS  Google Scholar 

  16. Vaheri, A., Ruoslahti, E., and Hovi, T., in ‘Control of proliferation in animal cells’ (edit. by Clarkson, B., and Baserga, R.) (Cold Spring Harbor Monograph, in the press).

  17. Vaheri, A., and Ruoslahti, E., Int. J. Cancer (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Serology and Bacteriology and Department of Virology, University of Helsinki, Haartmaninkatu 3, SF-00290, Helsinki, 29

    ERKKI RUOSLAHTI & ANTTI VAHERI

Authors
  1. ERKKI RUOSLAHTI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. ANTTI VAHERI
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RUOSLAHTI, E., VAHERI, A. Novel human serum protein from fibroblast plasma membrane. Nature 248, 789–791 (1974). https://doi.org/10.1038/248789a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/248789a0

  • Springer Nature Limited

This article is cited by

Search

Navigation