Abstract
Denaturation by alkali is activated by the ionisation of buried, weakly acidic side chains. Species variations are largely accounted for by replacements of one buried tyrosine and two cysteines.
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Perutz, M. Mechanism of denaturation of haemoglobin by alkali. Nature 247, 341–344 (1974). https://doi.org/10.1038/247341a0
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DOI: https://doi.org/10.1038/247341a0
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