Skip to main content
SpringerLink
Log in

Divinyl Ether-Maleic Anhydride (Pyran) Copolymer used to demonstrate the Effect of Molecular Weight on Biological Activity

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

DIVINYL ether and maleic anhydride form a 1:2 copolymer, which is reported to have the structure shown here1. It is commonly known as pyran copolymer, although we prefer to call it DIVEMA, an acronym for divinyl ethermaleic anhydride. It has been designated as NSC 46015 by the National Cancer Institute.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Butler, G. B., J. Polym. Sci., 48, 279 (1960).

    Article  ADS  CAS  Google Scholar 

  2. Espy, H. H., U. S. Patent, 3,224,943 (1965).

  3. Sandberg, J., and Goldin, A., Cancer Chemother. Rep., 55, 233 (1971).

    CAS  PubMed  Google Scholar 

  4. Merigan, T. C., and Regelson, W., N. Engl. J. Med., 277, 1283 (1967).

    Article  CAS  Google Scholar 

  5. Regelson, W., Adv. exp. med. Biol., 1, 315 (1967).

    Article  CAS  Google Scholar 

  6. Chirigos, M. A., Turner, W., Pearson, J., and Griffin, W., Int. J. Cancer, 4, 267 (1969).

    Article  CAS  Google Scholar 

  7. Chirigos, M. A., Comparative Leukaemia Research 1969, Bibl., Haemat., No. 36 (edit. by Dutcher, R. M.), 278 (Karger, Basel, Munchen, Paris, New York, 1970).

    Google Scholar 

  8. DeClercq, E., and Merigan, T. C., J. gen. Virol., 5, 359 (1969).

    Article  CAS  Google Scholar 

  9. Merigan, T. C., and Finkelstein, M. S., Virology, 35, 363 (1968).

    Article  CAS  Google Scholar 

  10. Schmidt, J. P., Pindak, F. F., Giron, D. J., and Ibarra, R. R., Texas Rep. biol. Med., 29, 133 (1971).

    CAS  Google Scholar 

  11. Richmond, J. Y., Infect. Immun., 3, 249 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Pindak, F. F., Infect. Immun., 1, 271 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Regelson, W., Munson, A., and Wooles, W., Int. Symp. Standards of Interferon and Interferon Inducers, London, 1969, Symp. Series Immunobiolog. Standards, 14, 227 (Karger, Basel, New York, 1970).

    Google Scholar 

  14. Regelson, W., and Munson, A. E., Ann. N.Y. Acad. Sci., 173, 831 (1970).

    Article  ADS  CAS  Google Scholar 

  15. Braun, W., Regelson, W., Yajima, Y., and Ishizuko, Proc. Soc. exp. Biol. Med., 133, 181 (1970).

    Article  Google Scholar 

  16. Hirsch, M. S., Black, P. H., Wood, M. L., and Monaco, A. P., Proc. Soc. exp. Biol. Med., 134, 309 (1970).

    Article  CAS  Google Scholar 

  17. Hirsch, M. S., Black, P. H., Wood, M. L., and Monaco, A. P., J. Immun., 108, 1312 (1972).

    CAS  PubMed  Google Scholar 

  18. Kapusta, M. A., and Mendelson, J., Arthr. Rheum., 12, 463 (1969).

    Article  CAS  Google Scholar 

  19. Shamash, Y., and Alexander, B., Biochim. biophys. Acta, 194, 449 (1969).

    Article  CAS  Google Scholar 

  20. Regelson, W., Miller, G., Breslow, D. S., and Engle, E. J., III, Abstr. Sixth Ann. Meeting Reticuloendothelial Society, paper 13 (1969).

  21. Munson, A. E., Regelson, W., Lawrence, jun., W., and Wooles, W. R., J. reticuloendothel. Soc., 7, 375 (1970).

    CAS  PubMed  Google Scholar 

  22. Butler, G. B., and Wu, C., Abstr. 164th Meeting Ann. Chem. Soc., New York, August, 1972 Section ORPL No. 73.

  23. Coll, H., in Gel Permeation Chromatography (edit. by Altgelt, K. H., and Segal, L.), 137 (Dekker, New York, 1971).

    Google Scholar 

  24. Butler, G. B., J. macromol. Sci. Chem., A 5, 219 (1971).

    Article  Google Scholar 

  25. Shyluck, S., J. Polym. Sci., 62, 317 (1962).

    Article  ADS  Google Scholar 

  26. Karrer, K., Humphreys, S. R., and Goldin, A., Int. J. Cancer, 2, 213 (1967).

    Article  CAS  Google Scholar 

  27. Hellmann, K., and Burrage, K., Nature, 224, 273 (1969).

    Article  ADS  CAS  Google Scholar 

  28. Leavitt, T. J., Merigan, T. C., and Freeman, J. M., J. Dis. Child., 121, 43 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Center, Hercules Incorporated, Wilmington, Delaware, 19899

    DAVID S. BRESLOW, ELEANOR I. EDWARDS & NORMAN R. NEWBURG

Authors
  1. DAVID S. BRESLOW
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. ELEANOR I. EDWARDS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. NORMAN R. NEWBURG
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRESLOW, D., EDWARDS, E. & NEWBURG, N. Divinyl Ether-Maleic Anhydride (Pyran) Copolymer used to demonstrate the Effect of Molecular Weight on Biological Activity. Nature 246, 160–162 (1973). https://doi.org/10.1038/246160a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/246160a0

  • Springer Nature Limited

This article is cited by

Search

Navigation