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Rapid and Selective Inhibition of the Synthesis of High Molecular Weight RNA in Yeast by Lomofungin

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Abstract

LOMOFUNGIN (1-carbomethoxy-5-formyl-4,6,8-trihydroxyphenazine), an antibiotic from Streptomyces lomodensis, inhibits the growth of bacteria, yeasts and fungi1,2. It has been suggested that in Saccharomyces cerevisiae, the primary action of the antibiotic is an inhibition of RNA synthesis2,3. Cano, Kuo and Lampen4 found that lomofungin inhibits three DNA-dependent RNA-polymerases extracted from S. cerevisiae. We have characterized the effects of lomofungin on RNA synthesis in the fission yeast, Schizosaccharomyces pombe.

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Authors and Affiliations

  1. Department of Zoology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT

    R. S. S. FRASER, J. CREANOR & J. M. MITCHISON

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  1. R. S. S. FRASER
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  2. J. CREANOR
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  3. J. M. MITCHISON
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FRASER, R., CREANOR, J. & MITCHISON, J. Rapid and Selective Inhibition of the Synthesis of High Molecular Weight RNA in Yeast by Lomofungin. Nature 244, 222–224 (1973). https://doi.org/10.1038/244222a0

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