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Transcription of IAP endogenous retroviruses is constrained by cytosine methylation

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Figure 1: Demethylation and transcriptional activation of IAP retroviruses in homozygous Dnmt-/- mutant mouse embryos.
Figure 2: Methylation history of IAP LTR sequences in mouse germ cells and embryos.

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Acknowledgements

We thank E. Michaud, E. Schon, S. Tilghman, T. Vasicek and R. Woychik for plasmid clones, and M. Turker for discussions. Supported by Fellowships from Cancerfonden of Sweden and The Leukemia Research Foundation to C.P.W., and by National Institutes of Health grants to J.R.C. and T.H.B.

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Authors and Affiliations

  1. Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W. 168th St, New York, 10032, New York, USA

    Colum P. Walsh & Timothy H. Bestor

  2. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, 15260, Pennsylvania, USA

    J. Richard Chaillet

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  1. Colum P. Walsh
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  2. J. Richard Chaillet
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  3. Timothy H. Bestor
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Correspondence to Timothy H. Bestor.

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Walsh, C., Chaillet, J. & Bestor, T. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet 20, 116–117 (1998). https://doi.org/10.1038/2413

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